Effect of Oral Lactate Ingestion on Appetite Regulation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-05-01

Study Completion Date

2024-08-31

Brief Summary

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The goal if this study is to determine how oral lactate ingestion affects markers of appetite regulation. Researchers will compare oral lactate ingestion to a sodium chloride placebo. Participants will consume the lactate or placebo solution and then have blood samples and assessments of appetite over the course of 90 min. Free-living energy intake will be measured for 3 days surrounding each experimental session.

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Detailed Description

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The purpose of this study is to explore the effects of oral lactate ingestion on appetite regulation in humans. To do this males and females will report to the laboratory for 2 experimental sessions completed in a counterbalanced, double-blinded manner. During one session a lactate solution will be ingested, in another session an equimolar sodium chloride solution will be ingested that matches the osmolarity of the lactate condition. Venous blood samples and subjective appetite perceptions will be obtained at five time points during each experimental session. Energy expenditure will be measured through accelerometers placed on the participants anterior thigh by an investigator on the morning the day before the session and worn over the experimental period (day before, day of, day after) recording their physical activity. Energy intake will be tracked using a smartphone mobile application called Keenoa over the same time period the accelerometers are worn.

Conditions

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Appetitive Behavior

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Participants will consume a sodium lactate and sodium chloride placebo in a double-blind, crossover design.

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

The allocation of lactate and placebo will be completed by a researcher not involved in data collection. Both the participant and the researchers collecting and analyzing the data will be blinded to the treatment allocation. This will be completed in a counter-balanced order.

Study Groups

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Sodium Lactate

Participants will received 0.45 g/kg of sodium lactate (SO179, Spectrum Chemical MFG Group) mixed with water. This will be mixed at a ratio of 30 mL per g of lactate. Lemon juice is added to the mixture at a specific ratio to balance the pH of the solution. Crystal light will also be added to avoid any taste differences between beverages.

Group Type EXPERIMENTAL

Sodium Lactate

Intervention Type OTHER

See arm/group description.

Sodium Chloride

Participants will receive a equimolar amount of sodium chloride (S9888, MilliporeSigma) mixed with water. The amount of water, lemon juice, and crystal light will be matched to that of the sodium lactate condition.

Group Type PLACEBO_COMPARATOR

Sodium Chloride

Intervention Type OTHER

See arm/group description.

Interventions

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Sodium Lactate

See arm/group description.

Intervention Type OTHER

Sodium Chloride

See arm/group description.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Deemed healthy using Canadian Society for Exercise Physiology Get Active Questionnaire
* Female participants must be eumenorrheic (menstrual cycle length between 21-35 days)

* Taking supplements or medications known to affect metabolism (e.g., creatine, beta-blockers)
* Currently pregnant or a pregnancy of \>3 months within the last 3 years,

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes