The Effect of Milk Proteins on Satiety, Food Intake and Metabolic Control (Glycemia) in Early Adulthood
NCT ID: NCT02471092
Last Updated: 2016-10-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
32 participants
INTERVENTIONAL
2014-11-30
2016-09-30
Brief Summary
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Detailed Description
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2. Intravenous blood samples will be collected from a subset of 12 (6 males and 6 females) participants for determination of insulin, satiety hormones, acetaminophen (gastric emptying rates), and determination of amino acid profiles.
Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
QUADRUPLE
Study Groups
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Water Control
Skim milk products. Water and permeate control; 250mL serving.
Skim milk products
Milk treatments will be served with 58g of breakfast cereal.
Skim Milk
Skim milk products. Skim milk (regular 80:20 protein ratio); 250mL serving.
Skim milk products
Milk treatments will be served with 58g of breakfast cereal.
High Protein Milk
Skim milk products. High protein milk (regular 80:20 protein ratio); 250mL serving.
Skim milk products
Milk treatments will be served with 58g of breakfast cereal.
High Protein Milk (Modified Ratio)
Skim milk products. High protein milk with modified protein ratio (40:60 ratio); 250 mL serving.
Skim milk products
Milk treatments will be served with 58g of breakfast cereal.
Skim Milk (Modified Ratio)
Skim milk products. Skim milk with modified protein ratio (40:60 ratio); 250 mL serving.
Skim milk products
Milk treatments will be served with 58g of breakfast cereal.
Interventions
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Skim milk products
Milk treatments will be served with 58g of breakfast cereal.
Eligibility Criteria
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Inclusion Criteria
* Healthy as determined by screening questionnaire
* Male or Female
* Non-smoking
* Normal fasting plasma glucose (\<5.5 mmol/L), but not below 3.3 mmol/L.
* Prior use of acetaminophen
Exclusion Criteria
* Weight loss or weight gain of more than 5 kg during the previous 2 months
* Taking medication or protein supplements (excluding oral contraceptive, multivitamins and folic acid)
* Serious medical condition (ie. Renal, liver)
* Lack of appetite or skipping breakfast
* Restrained eaters as defined as having a Three Factor Eating Questionnaire-Cognitive Restraint \>16
* Smoking
* Reported intolerance to milk or very low consumption (\< 2 servings per week) as assessed by in-person screening. Or not liking of the research foods.
* Food allergies or intolerances as well as anaphylactic or life-threatening allergies - food or otherwise
* Diabetes or other metabolic diseases that could interfere with study outcomes
* Acetaminophen, codeine or opioid allergy
* Pregnant or Breast Feeding
* Typical alcohol consumption of not more than 4 drinks per sitting
18 Years
30 Years
ALL
Yes
Sponsors
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University of Toronto
OTHER
Laval University
OTHER
University of Guelph
OTHER
Responsible Party
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Amanda Wright, Ph.D.
Associate Professor
Principal Investigators
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Amanda J Wright, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
University of Guelph
Locations
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University of Guelph- Human Nutraceutical Research Unit
Guelph, Ontario, Canada
Countries
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References
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Kung B, Turgeon SL, Vien S, Kubant R, El Khoury D, Wright AJ, Goff HD, Anderson GH. Role of Amino Acids in Blood Glucose Changes in Young Adults Consuming Cereal with Milks Varying in Casein and Whey Concentrations and Their Ratio. J Nutr. 2020 Dec 10;150(12):3103-3113. doi: 10.1093/jn/nxaa275.
Other Identifiers
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14JN004
Identifier Type: -
Identifier Source: org_study_id