Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
24 participants
INTERVENTIONAL
2025-05-13
2027-01-01
Brief Summary
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The main questions it aims to answer are:
* Does Lac-Phe reduce appetite in humans?
* Does Lac-Phe have glucose-lowering properties in humans?
During the study, participants will:
* receive an intravenous infusion of Lac-Phe on one study day and a NaCl infusion on another study day.
* drink a standard mixed meal
* eat an ad libitum meal test
* answer appetite questionnaires
* indirect calorimetry
* blood samples for hormone and substate analyses
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
OTHER
DOUBLE
Study Groups
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Lac-Phe
Intravenous infusion of Lac-Phe
N-lactoyl-phenylalanine
Intravenous infusion of N-lactoyl-phenylalanine (Lac-Phe)
Control
Intravenous infusion of NaCl
NaCl
0.9% isotonic NaCl infusion
Interventions
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N-lactoyl-phenylalanine
Intravenous infusion of N-lactoyl-phenylalanine (Lac-Phe)
NaCl
0.9% isotonic NaCl infusion
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Older than 18 years of age
* Hgb within a normal range (females: 7.3-9.5 mmol/L, males: 8.3-10.5 mmol/L)
* Females can be included if they are either postmenopausal or actively use hormonal contraception (e.g., oral contraceptive pill or hormone-releasing intrauterine device).
Exclusion Criteria
* Anemia
* Diabetes
* Ongoing cancer or other acute/chronic serious diseases (PI will determine)
* Inability to understand Danish or English
* Deemed unsuitable to participate by the PI and co-investigators.
18 Years
ALL
No
Sponsors
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University of Aarhus
OTHER
Responsible Party
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Locations
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SDCA research laboratory
Aarhus N, , Denmark
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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1-10-72-185-23
Identifier Type: -
Identifier Source: org_study_id
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