Effects of Fructose and Exercise on Hepatic Lipid Metabolism
NCT ID: NCT01121003
Last Updated: 2011-10-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
8 participants
INTERVENTIONAL
2010-05-31
2011-10-31
Brief Summary
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* after 4 days on a weight maintenance diet containing 5% simple sugars + low physical activity
* after 4 days on a weight maintenance diet containing 30% fructose + low physical activity
* after 4 days on a weight maintenance diet containing 30% fructose + high physical activity At the end of each of these 3 periods, fructose induced hepatic de novo lipogenesis (13C palmitate synthesis in response to ingestion of a 13C fructose load) and plasma VLDL-triglyceride kinetics (measured with a bolus of 2H-labeled glycerol) will be measured
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Low fructose diet/no exercise
weight maintenance, low sugar diet
high fructose diet/no exercise
weight maintenance, high fructose diet
high fructose diet+exercise
weight maintenance, high fructose diet+ exercise
Interventions
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weight maintenance, low sugar diet
weight maintenance, high fructose diet
weight maintenance, high fructose diet+ exercise
Eligibility Criteria
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Inclusion Criteria
* males
* BMI between 19 and 25
* low to moderate physical activity (\< 3 sessions/week)
Exclusion Criteria
* consumption of alcohol\>50g/week
* consumption of drugs or illicit substances
* food allergies
18 Years
30 Years
MALE
Yes
Sponsors
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Centre Hospitalier Universitaire Vaudois
OTHER
University of Lausanne
OTHER
Responsible Party
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Luc Tappy, MD
Professor of Physiology
Principal Investigators
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Luc Tappy, MD
Role: PRINCIPAL_INVESTIGATOR
University of Lausanne
Locations
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Centre Hospitalier Universitaire Vaudois
Lausanne, Canton of Vaud, Switzerland
Countries
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Other Identifiers
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Protocole 220/09
Identifier Type: -
Identifier Source: org_study_id