How Orally Consumed 3-hydroxybuturate Alters Metabolism

NCT ID: NCT02917252

Last Updated: 2017-04-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

6 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-02-01

Study Completion Date

2017-04-03

Brief Summary

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This study evaluate the metabolic effects of orally ingested ketone bodies. The study is conducted as a randomized, cross over study.

Detailed Description

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Subject participate for two separate days; i) intervention, ii) placebo. Intervention: subjects drink ketone body solution. Tracer kinetics on glucose and lipid metabolism is applied. Muscle tissue and adipose tissue biopsies are taken.

Placebo: subjects drink saline. Same sampling as on intervention day.

Conditions

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Acute Ketosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Intervention

Subjects drink 3-hydroxybuturate

Group Type ACTIVE_COMPARATOR

3-hydroxybuturate

Intervention Type OTHER

Drink of ketone bodies

Placebo

Subjects drink saline

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Drink of saline

Interventions

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3-hydroxybuturate

Drink of ketone bodies

Intervention Type OTHER

Placebo

Drink of saline

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* BMI 20-30

Exclusion Criteria

* Smoking
* alcohol or drug abuse
* Critically ill
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Aarhus University Hospital

Aarhus, , Denmark

Site Status

Countries

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Denmark

References

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Svart M, Rittig N, Pedersen SB, Jessen N, Moller N. Oral 3-hydroxybutyrate ingestion decreases endogenous glucose production, lipolysis, and hormone-sensitive lipase phosphorylation in adipose tissue in men: a human randomized, controlled, crossover trial. Diabet Med. 2021 Feb;38(2):e14385. doi: 10.1111/dme.14385. Epub 2020 Sep 22.

Reference Type DERIVED
PMID: 32794582 (View on PubMed)

Other Identifiers

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RM-1-10-72-157-16

Identifier Type: -

Identifier Source: org_study_id

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