Metabolomic Signature of Exogenous Ketosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

5 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-02-01

Study Completion Date

2023-04-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Ketone bodies are a fuel source and signaling molecule that are produced by your body during prolonged fasting or if you consistently eat at low-carbohydrate diet. Blood ketones can be used as a source of energy during fasting and are used by your brain as an alternative source of fuel to glucose. Previous studies have found that ketones, when consumed in form of a supplement drink, can increase blood ketone levels and lower blood glucose, the amount of sugar in your blood. This is of potential interest for individuals with high blood sugar, such as people living with type 2 diabetes. However, how ketone supplements impact metabolism is not fully understood but using high throughput analysis techniques that can characterize hundreds to thousands of metabolites in the blood (known as "metabolomics") may allow researchers to discover novel compounds within the body that are altered by ketone supplements. This will improve our understanding of how ketones impact metabolism and guide future research.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The Effect of Different Ketone Supplements on β-OHB and Blood Glucose in Healthy Individuals

NCT05273411

Ketosis Blood Glucose

COMPLETED NA

The Effects of Exogenous Ketones on Glucose Tolerance

NCT04088617

Dietary Supplement: Ketone Supplement Dietary Supplement: Placebo

COMPLETED PHASE1

Exogenous Ketones and Glucose Tolerance

NCT03461068

Ketones Dietary Supplements

COMPLETED PHASE1

Ketone Plasma Kinetics After Oral Intake of Different Ketogenic Formulae

NCT05058157

Healthy Men and Women

UNKNOWN NA

Effects of Exogenous Ketones in Healthy Young Adults

NCT03452761

Healthy Young Adults

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Ketosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Single-arm pilot study

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Ketone monoester

0.75 g/kg body mass of ketone monoester to be consumed within 5 minutes with venous blood samples obtained pre-ingestion, and 30-, 60- and 90-minutes post-ingestion.

Group Type EXPERIMENTAL

(R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester

Intervention Type DIETARY_SUPPLEMENT

Participants will consume a ketone monoester drink (0.75 k/kg body mass) with venous blood samples obtained before and after (30, 60 and 90 minutes) drink consumption.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

(R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester

Participants will consume a ketone monoester drink (0.75 k/kg body mass) with venous blood samples obtained before and after (30, 60 and 90 minutes) drink consumption.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* over the age of 18 years
* able to fast overnight

Exclusion Criteria

* being a competitive endurance athlete
* following a ketogenic diet, low-calorie diet, periodic fasting regimen, or regular consuming ketone supplements
* being unable to travel to and from the university
* being pregnant or planning to become pregnant during the study
* having been diagnosed with a chronic disorder of glucose or fat metabolism, including type 2 diabetes, chronic pancreatitis, or gallbladder disease
* being unable to read or communicate in English

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes