Effect of the Natural Sweeteners Erythritol and Xylitol on Gut Microbiota and Glucose Metabolism in Obese Volunteers
NCT ID: NCT02824614
Last Updated: 2025-07-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
64 participants
INTERVENTIONAL
2016-06-30
2020-02-29
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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Control
20 obese, non-diabetic candidates will serve as control-group. All assessments are carried out just as in the intervention groups.
No interventions assigned to this group
E967-Xylitol
20 obese, non-diabetic candidates will receive a daily dose of 24g of xylitol.
E967-Xylitol
E968-Erythritol
20 obese, non-diabetic candidates will receive a daily dose of 36g of erythritol.
E968-Erythritol
Interventions
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E967-Xylitol
E968-Erythritol
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Aged 18- max. 55 years
* Otherwise healthy.
Exclusion Criteria
* Diabetes mellitus
* Arterial Hypertension with medication
* Dyslipidaemia with medication
* Known chronic hepatic disease (NASH, hepatitis).
* Known renal disease: kidney failure
* Pregnancy
* Intake of proton pump inhibitors (PPIs) on a regular basis
* Intake of antibiotics within the last 3 months before inclusion
* Intake of pro or prebiotics
* Chronical diseases of the gastrointestinal tract, history of gastrointestinal surgery with major changes to the gastrointestinal tract
* Substance abuse, alcohol abuse.
* Inability to follow procedures due to psychological disorders, dementia or insufficient knowledge of project language (German).
18 Years
55 Years
ALL
No
Sponsors
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University Hospital, Basel, Switzerland
OTHER
Responsible Party
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Principal Investigators
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Christoph Beglinger, MD
Role: STUDY_CHAIR
St. Claraspital klinische Forschungsabteilung
Locations
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Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital
Oslo, , Norway
Endoscopic and Minimally Invasive Surgery Clinic of Stavropol State Medical University
Stavropol, , Russia
St Claraspital
Basel, , Switzerland
Countries
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Other Identifiers
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Poly Gut
Identifier Type: -
Identifier Source: org_study_id
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