Effect of Amino Acids and Sugar Alcohols on Gastric Emptying and Release of Satiation Peptides in Humans
NCT ID: NCT02563847
Last Updated: 2015-09-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2014-05-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
DOUBLE
Study Groups
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0.52 g L-Tryptophan
0.52 g L-Tryptophan in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
0.52 g L-Tryptophan
50 mg 13C-sodium acetate
1.56 g L-Tryptophan
1.56 g L-Tryptophan in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
1.56 g L-Tryptophan
50 mg 13C-sodium acetate
1.56 g L-Leucine
1.56 g L-Leucine in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
1.56 g L-Leucine
50 mg 13C-sodium acetate
50 g Xylitol
50 g Xylitol in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
50 g Xylitol
50 mg 13C-sodium acetate
75 g Erythritol
75 g Erythritol in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
75 g Erythritol
50 mg 13C-sodium acetate
75 g Glucose
75 g Glucose in 300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
75 g Glucose
50 mg 13C-sodium acetate
Tap water
300 mL tap water (plus 50 mg 13C-sodium acetate) given via nasogastric tube
300 mL tap water
50 mg 13C-sodium acetate
Interventions
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0.52 g L-Tryptophan
1.56 g L-Tryptophan
1.56 g L-Leucine
50 g Xylitol
75 g Erythritol
75 g Glucose
300 mL tap water
50 mg 13C-sodium acetate
Eligibility Criteria
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Inclusion Criteria
* Healthy obese subjects with a body-mass index of \> 30
* Normal eating habits (no diets; no dietary changes; no special dietary habits, such as vegetarian/vegan)
* Age 18-40 years
* Stable body weight for at least three months
Exclusion Criteria
* Substance abuse
* Regular intake of medications (except for oral contraceptives)
* Medical or psychiatric illness
* History of gastrointestinal disorders
* Food allergies
* Pregnancy, breast feeding
18 Years
40 Years
ALL
Yes
Sponsors
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University Hospital, Basel, Switzerland
OTHER
Responsible Party
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Principal Investigators
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Christoph Beglinger, Prof.
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Basel, Switzerland
Locations
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University Hospital Basel, Phase 1 Research Unit
Basel, , Switzerland
Countries
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References
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Meyer-Gerspach AC, Hafliger S, Meili J, Doody A, Rehfeld JF, Drewe J, Beglinger C, Wolnerhanssen B. Effect of L-Tryptophan and L-Leucine on Gut Hormone Secretion, Appetite Feelings and Gastric Emptying Rates in Lean and Non-Diabetic Obese Participants: A Randomized, Double-Blind, Parallel-Group Trial. PLoS One. 2016 Nov 22;11(11):e0166758. doi: 10.1371/journal.pone.0166758. eCollection 2016.
Other Identifiers
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EKBB 2014/072
Identifier Type: -
Identifier Source: org_study_id