Acute Effects of the Two Alternative Sweeteners D-allulose and Erythritol on Metabolism

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-09-01

Study Completion Date

2020-09-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this project is to investigate the effect of intragastric (ig) D-allulose on metabolic parameters in general and to investigate the effect of sweet taste receptor blockade on GI hormone responses, glycemic control, gastric emptying (GE) rates and appetite-related sensations to ig administration of erythritol and D-allulose.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effects of Oral Pre-loads on Subsequent Energy Intake

NCT04713137

Energy Intake Gastrointestinal Hormones Glycemic Control +2 more

COMPLETED NA

Assessments of Metabolic Responses to Acute Oral Administration of Sucrose, Glucose, and Fructose

NCT06799715

Gastrointestinal Hormones Glycemic Control Blood Coagulation Function +1 more

RECRUITING NA

Effects of Artificial Sweetener on Gastrointestinal (GI) Peptide Secretion

NCT00978900

Healthy

COMPLETED PHASE1

Assessment of Reward Responses to Erythritol Using Flavor Preference Learning

NCT05279183

Reward Responses Gastrointestinal Hormones Glycemic Control +3 more

COMPLETED NA

Effects of Oral Xylitol on Subsequent Energy Intake

NCT05671965

Energy Intake Gastrointestinal Hormones Glycemic Control +2 more

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Erythritol (natural non-caloric sweetener) could be an ideal candidate substitute for sugar as it may reduce caloric intake without compensatory overeating or earlier return of hunger. Moreover, it may serve as a physiological tool to disentangle the effects of gastrointestinal (GI) sweet taste receptor stimulation, (an)orexigenic hormone secretion, and glucose metabolism/caloric content on food intake regulation in vivo in humans. However, its effects on appetite, satiation, and satiety have not been studied systematically. Moreover, the mechanisms underlying erythritol-induced anorexigenic GI hormone release have not been investigated so far.

D-allulose is a sugar substitute with almost zero calories and is naturally occurring in small quantities. Apart from its use as sugar replacement, D-allulose seems to favorably affect glycemic control and metabolism as could be shown in animal trials and in a few human trials. However, to date the effects of D-allulose on GI hormone secretion, appetite-related sensations and glycemic control, are not or insufficiently studied in humans.

The aim of this project is therefore to investigate the effect of intragastric (ig) D-allulose on metabolic parameters in general and to investigate the effect of sweet taste receptor blockade on GI hormone responses, glycemic control, gastric emptying (GE) rates and appetite-related sensations to ig administration of erythritol and D-allulose.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Physiological Satiation Mechanisms

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.