Acute Effects of Artificial Sweeteners or Sugar on Hemodynamic and Metabolic Stress Responses
NCT ID: NCT02973334
Last Updated: 2017-12-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
NA
12 participants
INTERVENTIONAL
2015-10-31
2017-07-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
The experimental test was divided into 5 stages:
1. a 90 minutes baseline period (t=0-90 min),
2. a 30-min mental stress (MS; t=90-120 min), consisting in 5-min periods of Stroop's color word conflict test alternated with 5-min periods of mental arithmetic test.
3. a 30-min MS recovery period (t=120-150),
4. a 3-min cold pressure test (CPT) was carried out, aiming at immersing one volunteer's forearm in an ice water container at 3°C,
3\) a 15-min CPT recovery period (t=120-150). 60 min after the beginning of the metabolic test, volunteers will drink 25 mL every 15 min, after 10-sec mouth rinsing, of either an artificially- or sugar-sweetened beverages or water (control).
Hemodynamic stress responses will be measured by repeated blood pressure, heart rate and cardiac output. Repeated venous blood samples will allow to assess metabolic stress responses.
Each condition (water, artificial sweeteners and sugar) will be preceded by a 2-day run-in period.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Keywords
Explore important study keywords that can help with search, categorization, and topic discovery.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
CROSSOVER
BASIC_SCIENCE
TRIPLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Sugar
Effects of ingestion of sugar-sweetened beverages on acute stress response
Ingestion of sugar-sweetened beverages
From t=60 to the end of the metabolic test, volunteers will ingest 7 beverages containing sugar (25 mL / beverage) every 15 minutes after 10-sec mouth rinsing.
Artificial sweetener
Effects of ingestion of artificially-sweetened beverages on acute stress response
Ingestion of artificially-sweetened beverages
From t=60 to the end of the metabolic test, volunteers will ingest 7 beverages containing non nutritive sweeteners (25 mL / beverage) every 15 minutes after 10-sec mouth rinsing.
Water
Effects of ingestion of water on acute stress response
Ingestion of water
From t=60 to the end of the metabolic test, volunteers will ingest 7 water beverages (25 mL / beverage) every 15 minutes after 10-sec mouth rinsing.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Ingestion of artificially-sweetened beverages
From t=60 to the end of the metabolic test, volunteers will ingest 7 beverages containing non nutritive sweeteners (25 mL / beverage) every 15 minutes after 10-sec mouth rinsing.
Ingestion of sugar-sweetened beverages
From t=60 to the end of the metabolic test, volunteers will ingest 7 beverages containing sugar (25 mL / beverage) every 15 minutes after 10-sec mouth rinsing.
Ingestion of water
From t=60 to the end of the metabolic test, volunteers will ingest 7 water beverages (25 mL / beverage) every 15 minutes after 10-sec mouth rinsing.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Caucasian
* Normal Body Mass Index (18.5 ≤BMI≤ 25 kg/m2)
* Monophasic oral contraceptive
Exclusion Criteria
* History or actual psychologic/cardiovascular troubles
* Anemia anamnesis
* Being Pregnant
* Weight \< 50 kg
* Blood donation or participation to another study \< 8 weeks
* Claustrophobia
* Consumption of sugar/artifically-sweetened beverages drinks \> 5 dL/d
* Visual disturbances (daltonism)
* Low to moderate physical activity (\> 4h/wk)
* Smoker and narcotic consumption
* Caffeine (\> 400 mg/d) and/or alcohol (\> 10g/d) consumption
* Medical treatment
* Weight variation \> 3kg during the last month
18 Years
40 Years
FEMALE
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
University of Lausanne
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Luc Tappy, MD
Full Professor
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Luc TAPPY, Professor
Role: PRINCIPAL_INVESTIGATOR
Department of Physiology, University of Lausanne, Switzerland
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
University of Lausanne
Lausanne, , Switzerland
Countries
Review the countries where the study has at least one active or historical site.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
316/15
Identifier Type: -
Identifier Source: org_study_id