The Influence of Sweet Substrates on Hunger, Gastrointestinal Hormones and the Migrating Motor Complex
NCT ID: NCT02891525
Last Updated: 2016-09-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
12 participants
INTERVENTIONAL
2015-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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50g glucose intragastric
50g glucose dissolved in 250mL tap water given via nasogastric tube
50g glucose
25g fructose intragastric
25g glucose dissolved in 250mL tap water given via nasogastric tube
25g fructose
220mg acesulfame-K intragastric
220mg acesulfame-K dissolved in 250mL tap water given via nasogastric tube
220mg acesulfame-K
250mL tap water intragastric
250mL tap water given via nasogastric tube
250mL tap water
Interventions
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50g glucose
25g fructose
220mg acesulfame-K
250mL tap water
Eligibility Criteria
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Inclusion Criteria
* Female or male subjects aged 18 to 60
* Subject is capable and willing to give informed consent
* Female volunteers of child bearing potential must use oral, injected or implanted hormonal methods of contraception
Exclusion Criteria
* GI diseases, major abdominal surgery
* Volunteers that have food allergies, especially fructose intolerance
* Major psychiatric illnesses
* Volunteers that use drugs affecting the GI tract or the central nervous system
* Volunteers suffering from an endocrine disease such as diabetes, Cushing's disease, Addison's disease, hypothalamic tumor
* Volunteers that have undergone surgical procedure for weight loss
18 Years
60 Years
ALL
Yes
Sponsors
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Universitaire Ziekenhuizen KU Leuven
OTHER
Responsible Party
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Principal Investigators
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Jan Tack, Prof.
Role: PRINCIPAL_INVESTIGATOR
Universitaire Ziekenhuizen KU Leuven
References
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Meyer-Gerspach AC, Biesiekierski JR, Deloose E, Clevers E, Rotondo A, Rehfeld JF, Depoortere I, Van Oudenhove L, Tack J. Effects of caloric and noncaloric sweeteners on antroduodenal motility, gastrointestinal hormone secretion and appetite-related sensations in healthy subjects. Am J Clin Nutr. 2018 May 1;107(5):707-716. doi: 10.1093/ajcn/nqy004.
Other Identifiers
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GIMotilitySweetTaste
Identifier Type: -
Identifier Source: org_study_id
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