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Effects of Consuming Artificial Sweeteners and Sugar on Cerebral and Physiological Responses

NCT ID: NCT02853773

Last Updated: 2017-10-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-02-29

Study Completion Date

2017-09-29

Brief Summary

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This study aims at investigating the acute influence of artificially sweetened beverages consumption (as compared with sugar-sweetened beverages and water consumption) on brain responses to the viewing of food images, on physiological responses (gut-derived hormones and lipid metabolites) and on the food intake behavior.

Detailed Description

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This study is made on a randomized controlled crossover design including three conditions (water, sugar, artificial sweeteners). Measurements will be performed in fasting and fed conditions. The test-meal will comprise either an artificially or sugar-sweetened beverage or water (control). The spatio-temporal brain dynamics to the viewing of food pictures will be assessed by means of electroencephalography (EEG) recordings and electrical neuroimaging analyses. Venous blood and urine will be collected. Blood pressure, cardiac frequency and bio-impedance measurements will be performed. Food intake behavior will be assessed by means of questionnaires and a free-choice buffet. Each tested condition (water, sugar, artificial sweeteners) will be preceded by a run-in period during which the participants' diet will be controlled (2-day isoenergetic diet).

Conditions

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Normal Subjects

Keywords

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sweeteners sugar EEG food viewing food intake

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Artificial sweetener

Effects of co-ingestion of artificially sweetened beverage on the response to a test meal

Group Type EXPERIMENTAL

ingestion of a test meal with sweetener

Intervention Type OTHER

participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with artificially sweetened drinks

Sugar

Effects of co-ingestion of sugar-sweetened beverage on the response to a test meal

Group Type ACTIVE_COMPARATOR

ingestion of a test meal with sweetener

Intervention Type OTHER

participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with sugary drinks drinks

Water

Effects of co-ingestion of water on the response to a test meal

Group Type ACTIVE_COMPARATOR

ingestion of a test meal with water

Intervention Type OTHER

participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with waters

Interventions

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ingestion of a test meal with sweetener

participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with artificially sweetened drinks

Intervention Type OTHER

ingestion of a test meal with sweetener

participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with sugary drinks drinks

Intervention Type OTHER

ingestion of a test meal with water

participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with waters

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy
* Caucasian
* Right-handed
* Weak to normal physical activity (\< 3hours per week)
* Normal-weight (19\<BMI\<25 kg/m2)
* Regular consumption of sugar-sweetened beverages (\>33cl per week)

Exclusion Criteria

* Consumption of artificially sweetened beverages exceeding 33cl per week
* Diabetes
* Cardiovascular, kidney, hepatic and/or psychological disorders
* Blood pressure at rest \> 140/90mmHg
* Body weight \< 50kg
* Hemoglobin \< 13.5g/dl
* Ferritin \< 50microg/l
* Drug consumption
* Alcohol consumption (\>10g/day)
* Smoking
* Any particular diet (e.g. vegetarianism), food allergy and/or intolerance
* Body weight gain or loss of \>3kg during the last 3 months
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Lausanne Hospitals

OTHER

Sponsor Role collaborator

University of Lausanne

OTHER

Sponsor Role lead

Responsible Party

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Luc Tappy, MD

Full professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Luc Tappy, Professor

Role: PRINCIPAL_INVESTIGATOR

Department of Physiology, University of Lausanne, Switzerland

Locations

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Department of Physiology

Lausanne, Canton of Vaud, Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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353/15

Identifier Type: -

Identifier Source: org_study_id