Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
24 participants
OBSERVATIONAL
2013-02-28
2016-12-31
Brief Summary
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Their intestinal de novo lipogenesis will be estimated by measuring 13C-palmitate on triglyceride-rich lipoprotein particles associated with apoB48 in blood in sub-study 1
Their exogenous lipid absorption kinetics will be assessed by measuring 13C palmitate on triglyceride-rich lipoprotein particles associated with apoB48 in sub-study 2
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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non-obese healthy subjects
subjects with BMI\<25 and no known disease
fat+protein meal
cream+ whey protein
Fat + protein + 13C fructose meal
cream+ whey protein +13C fructose
Fat+protein+13C fructose+glucose meal
Cream + whey protein + glucose:13C fructose mixture
13C Fat + whey protein
cream labelled with 13C palmitate + whey protein
13C Fat + whey protein + glucose+ glucose meal
cream labelled with 13C palmitate + whey protein + glucose:fructose mixture
post-gastric bypass
post-obese subjects 12-48 months after Roux-en-Y gastric bypass
fat+protein meal
cream+ whey protein
Fat + protein + 13C fructose meal
cream+ whey protein +13C fructose
13C Fat + whey protein + glucose+ glucose meal
cream labelled with 13C palmitate + whey protein + glucose:fructose mixture
matched control subjects
Nonobese, healthy subjects of similar age, weight, and gender ratio, than post-bypass subjects
fat+protein meal
cream+ whey protein
Fat + protein + 13C fructose meal
cream+ whey protein +13C fructose
13C Fat + whey protein + glucose+ glucose meal
cream labelled with 13C palmitate + whey protein + glucose:fructose mixture
Interventions
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fat+protein meal
cream+ whey protein
Fat + protein + 13C fructose meal
cream+ whey protein +13C fructose
Fat+protein+13C fructose+glucose meal
Cream + whey protein + glucose:13C fructose mixture
13C Fat + whey protein
cream labelled with 13C palmitate + whey protein
13C Fat + whey protein + glucose+ glucose meal
cream labelled with 13C palmitate + whey protein + glucose:fructose mixture
Eligibility Criteria
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Inclusion Criteria
* sex male or female
* less than 2 kg body weight change over the past 3 months subjects
Exclusion Criteria
* alcohol consumption \>20g/day
* severe eating disorders
* severe psychological problems
* vegetarian diet or other specific diet
* consumption of illicit substances
* pregnancy
* weight gain or weight loss \> 1 kg in the last 3 months
25 Years
50 Years
ALL
Yes
Sponsors
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University of Lausanne
OTHER
Responsible Party
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Luc Tappy, MD
Professor
Locations
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Centre Hospitalier Universitaire Vaudois
Lausanne, Canton of Vaud, Switzerland
Countries
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References
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Theytaz F, de Giorgi S, Hodson L, Stefanoni N, Rey V, Schneiter P, Giusti V, Tappy L. Metabolic fate of fructose ingested with and without glucose in a mixed meal. Nutrients. 2014 Jul 15;6(7):2632-49. doi: 10.3390/nu6072632.
Other Identifiers
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193/11
Identifier Type: -
Identifier Source: org_study_id
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