Effects of Exercise on Fructose Metabolism

NCT ID: NCT01866215

Last Updated: 2014-06-04

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 8 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-05-31
• Study Completion Date: 2014-01-31

Brief Summary

A high fructose diet increases fasting and post-prandial triglyceride (TG) concentrations in sedentary healthy human subjects.These effects may be secondary to fructose-induced hepatic de novo lipogenesis. Recent evidence indicate that exercise can prevent fructose induced dyslipidemia.This study will evaluate

1. how exercise effects the metabolic fate of oral fructose 1a) when exercise is performed before fructose ingestion 1b) when exercise is performed after fructose ingestion Metabolic effects of exercise will be assessed in healthy male subjects by measuring fructose oxidation (13CO2 production), fructose conversion into glucose (13C glucose concentrations in blood) and hepatic fructose conversion into lipid (13C palmitate-very low density lipoprotein (VLDL) concentrations in blood) after ingestion of 13C-labelled fructose meals

2. how fructose and protein modulate muscle glycogen and intramyocellular lipid repletion after exercise Healthy male subjects will be fed various fructose, glucose, lipid and whey protein meals after a glycogen/intramyocellular lipid depleting exercise. The effects of meals' composition will be assessed after 24 hours by measuring intramyocellular lipids and glycogen using proton-magnetic resonance spectroscopy (MRS).

Conditions

Healthy Subjects

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Study1a

exercice performed 90 min before 13C fructose meal ingestion

Group Type: EXPERIMENTAL

exercise

Intervention Type: OTHER

cycling at 100W during 60 min

study 1b

exercise performed 90 min after 13C fructose meal ingestion

Group Type: EXPERIMENTAL

exercise

Intervention Type: OTHER

cycling at 100W during 60 min

study 1c

no exercise

Group Type: NO_INTERVENTION

No interventions assigned to this group

study 2a

meals containing fructose, cream and whey proteins over 24 hours after a glycogen/intramyocellular lipid depleting exercise

Group Type: EXPERIMENTAL

fructose

Intervention Type: DIETARY_SUPPLEMENT

isocaloric nutrition with fructose, cream and whey protein during the 24 hour following a glycogen/intramyocellular lipid depleting exercise

study 2b

meals containing glucose, cream and whey proteins over 24 hours after a glycogen/intramyocellular lipid depleting exercise

Group Type: ACTIVE_COMPARATOR

glucose

Intervention Type: DIETARY_SUPPLEMENT

isocaloric nutrition with glucose, cream and whey protein during the 24 hour following a glycogen/intramyocellular lipid depleting exercise

Interventions

exercise

cycling at 100W during 60 min

Intervention Type: OTHER

fructose

isocaloric nutrition with fructose, cream and whey protein during the 24 hour following a glycogen/intramyocellular lipid depleting exercise

Intervention Type: DIETARY_SUPPLEMENT

glucose

isocaloric nutrition with glucose, cream and whey protein during the 24 hour following a glycogen/intramyocellular lipid depleting exercise

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• males
• 18-40 years old
• 19 kg/m2>BMI>25kg/m2
• moderate to high usual physical activity
• non-smokers

Exclusion Criteria

• family history of diabetes mellitus
• ECG anomaly
• any medication
• participation to blood spending or other clinical study in the 3 months before the beginning of this study
• consumption of drugs
• consumption of more than 50g alcool/week
• family history of food intolerance

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Bern

OTHER

Sponsor Role: collaborator

Centre Hospitalier Universitaire Vaudois

OTHER

Sponsor Role: collaborator

University of Lausanne

OTHER

Sponsor Role: lead

Responsible Party

Luc Tappy, MD

Professor of Physiology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Luc Tappy, MD

Role: PRINCIPAL_INVESTIGATOR

University of Lausanne

Locations

Centre Hospitalier Universitaire Vaudois

Lausanne, Canton of Vaud, Switzerland

Countries

Switzerland

References

Rosset R, Lecoultre V, Egli L, Cros J, Dokumaci AS, Zwygart K, Boesch C, Kreis R, Schneiter P, Tappy L. Postexercise repletion of muscle energy stores with fructose or glucose in mixed meals. Am J Clin Nutr. 2017 Mar;105(3):609-617. doi: 10.3945/ajcn.116.138214. Epub 2017 Jan 18.

Reference Type: DERIVED

PMID: 28100512 (View on PubMed)

Egli L, Lecoultre V, Cros J, Rosset R, Marques AS, Schneiter P, Hodson L, Gabert L, Laville M, Tappy L. Exercise performed immediately after fructose ingestion enhances fructose oxidation and suppresses fructose storage. Am J Clin Nutr. 2016 Feb;103(2):348-55. doi: 10.3945/ajcn.115.116988. Epub 2015 Dec 23.

Reference Type: DERIVED

PMID: 26702120 (View on PubMed)

Other Identifiers

University of Lausanne

Identifier Type: -

Identifier Source: org_study_id