The Metabolic Effects of a High Fructose Versus a High Glucose Diet in Overweight Men
NCT ID: NCT01050140
Last Updated: 2012-07-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
32 participants
INTERVENTIONAL
2010-01-31
2011-04-30
Brief Summary
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A high fructose diet (HFrD) results in greater visceral adiposity and systemic insulin resistance than a high glucose diet. The effects of fructose on liver fatty acid and ATP stores, systemic oxidative stress and cardiovascular status are not fully known.
Detailed Description
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1. The ultimate fate of this increased hepatic fatty acid production following a high fructose vs. glucose diet
2. The effect of a high fructose vs. glucose diet on liver ATP stores
3. The effect of a high fructose vs. glucose diet on markers of oxidative stress
4. The effect of a high fructose vs. glucose diet on cardiovascular status
Factors critical to carbohydrate metabolism such as systemic insulin resistance, body composition, energy expenditure, physical activity will also be assessed.
32 centrally overweight healthy males with a low baseline fructose intake will be recruited. They will be randomised double blindly to receive 25% of their dietary energy requirements from either fructose or glucose for 14 days.
The sugars will first be taken in an energy balanced and then an overfeeding setting.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
QUADRUPLE
Study Groups
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fructose
25% dietary energy from fructose
high sugar diet
25% of dietary energy from fructose or glucose
glucose
25% dietary energy from glucose
high sugar diet
25% of dietary energy from fructose or glucose
Interventions
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high sugar diet
25% of dietary energy from fructose or glucose
Eligibility Criteria
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Inclusion Criteria
2. Waist \> hip circumference
3. Age 18-50 years
4. Male
Exclusion Criteria
2. Active health problems
3. Contraindications to MRI scanning
4. Symptoms of functional bloating or irritable bowel syndrome
5. Abnormal liver or renal function tests
6. Random glucose greater than 11.0 mmol/L
7. Evidence of metabolic or viral liver disease as screened for by hepatitis B and C serology, and ferritin.
8. Alcohol intake \> 21 units per week
9. Vegetarianism
10. Normal daily fructose intake from drinks greater than that in 500ml of coca cola
11. Abnormal carbohydrate energy contribution to baseline diet - defined as greater than 2 standard deviations from the mean of the National Diet and Nutrition Survey 2002 data
18 Years
50 Years
MALE
Yes
Sponsors
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University of Nottingham
OTHER
Responsible Party
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Principal Investigators
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Ian A Macdonald, PhD
Role: STUDY_CHAIR
School of Biomedical Sciences, Nottingham University, UK
Richard D Johnston, MRCP
Role: PRINCIPAL_INVESTIGATOR
School of Biomedical Sciences, Nottingham University, UK
Locations
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School of Biomedical Sciences, University of Nottingham
Nottingham, Nottinghamshire, United Kingdom
Countries
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References
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Johnston RD, Stephenson MC, Crossland H, Cordon SM, Palcidi E, Cox EF, Taylor MA, Aithal GP, Macdonald IA. No difference between high-fructose and high-glucose diets on liver triacylglycerol or biochemistry in healthy overweight men. Gastroenterology. 2013 Nov;145(5):1016-1025.e2. doi: 10.1053/j.gastro.2013.07.012. Epub 2013 Jul 19.
Other Identifiers
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D/10/2009
Identifier Type: -
Identifier Source: org_study_id