A Comparison of the Neurocognitive and Metabolic Effects of Fructose, Glucose, High Fructose Corn Syrup and Sucrose at Normal Population Consumed Levels in Adults Ages 20-60 Years Old

NCT ID: NCT02278042

Last Updated: 2015-04-10

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 225 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-06-30

Brief Summary

The purpose of this study is to investigate the acute and chronic effects of consumption fructose containing sugars and glucose in a real word setting when consumed in a manner and amount typical in the American diet.

Detailed Description

Detailed description (Why and How?) Fructose is known to be metabolized differently than the other common monosaccharides. In addition to the well know lipogenic effects, more recent evidence has shown that the acute changes in hormones and metabolic parameters that control appetite and energy regulation when with fructose consumption may promote caloric overconsumption and, in the long-term, weight gain and deteriorations in insulin sensitivity. However, fructose is rarely consumed in isolation, but instead is consumed in combination with other sugars (with glucose in the case of the two most common sources of fructose: high fructose corn syrup (HFCS) and sucrose, or as part of a mixed macronutrient meal. As such, the practical significance of these short-term findings of isolated monosaccharide consumption is limited.

AIM 1: investigate the response to ten weeks of daily consumption of typical levels of different fructose containing sugars and glucose on measures of glucose and insulin metabolism.

AIM 2: To investigate whether ten weeks of daily consumption changes the fat content of the liver, skeletal muscles or abdomen.

Conditions

Conditions: None. Focus: Understanding the Obesogenic Potential of Fructose Containing Sugars

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: SINGLE

Study Groups

9% Fuctose

Milk Sweetened with fructose in an amount that the added fructose contributes 9% of the calories required for weight maintenance.

Group Type: ACTIVE_COMPARATOR

Beverage Consumption

Intervention Type: OTHER

18% Sucrose

Milk Sweetened with sucrose in an amount that the added sucrose contributes 18% of the calories required for weight maintenance.

Group Type: ACTIVE_COMPARATOR

Beverage Consumption

Intervention Type: OTHER

18% High fructose corn syrup

Milk Sweetened with High fructose corn syrup (HFCS) in an amount that the added HFCS contributes 18% of the calories required for weight maintenance.

Group Type: ACTIVE_COMPARATOR

Beverage Consumption

Intervention Type: OTHER

9% Glucose

Milk Sweetened with glucose in an amount that the added glucose contributes 9% of the calories required for weight maintenance.

Group Type: ACTIVE_COMPARATOR

Beverage Consumption

Intervention Type: OTHER

Unsweetened Milk

Unsweetened milk consumed in amount the contributes 18% of the calories required for weight maintenance.

Group Type: ACTIVE_COMPARATOR

Beverage Consumption

Intervention Type: OTHER

Interventions

Beverage Consumption

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Male or female between the ages of 20-60 years of age.
• Body Mass Index (BMI) 21.0 - 35.0

Exclusion Criteria

• More than a 3 percent change in weight within the 3 months prior to enrollment in the study.
• History of thyroid disease, but not taking medication or medication dosage changed one or more times over last 6 months. History of thyroid disease and on a stable dose of prescription medication for 6 months or longer is acceptable.
• Currently taking a prescription medication for weight loss. If subject is willing to discontinue prescription medication(s) immediately and willing to refrain from taking medication(s) for duration of study, he/she may be enrolled after a four-week washout period.
• Currently taking any over-the-counter weight loss supplement(s). If subject is willing to discontinue supplement(s) immediately and willing to refrain from taking supplement(s) for duration of study, he/she may be enrolled after a two-week washout period.
• Currently enrolled in commercial weight loss program (e.g. Jenny Craig, Weight Watchers) or self-help group (e.g. TOPS, Overeaters Anonymous). If subject is willing to discontinue program immediately and willing to refrain from program for duration of study, he/she may be included after a two-week washout period.
• Diagnosed with prediabetes or frank diabetes (Type I or Type II).
• History of major surgery within three months of enrollment.
• History of heart problems (e.g. angina, bypass surgery, MI, etc.) within three months prior to enrollment.
• Presence of implanted cardiac defibrillator or pacemaker.
• Uncontrolled hypertension/high blood pressure.
• History of a surgical procedure for weight loss at any time (e.g. gastroplasty, gastric by-pass, gastrectomy or partial gastrectomy).
• Gastrointestinal disorders including chronic malabsorptive conditions, peptic ulcer disease, Crohn's disease, chronic diarrhea or active gallbladder disease.
• History of inflammatory bowel disease
• History of fatty liver
• History or presence of cancer. Persons with successfully resected basal cell carcinoma of the skin may be enrolled if treatment completed more than 6 months prior to enrollment.
• History of clinically diagnosed eating disorders including anorexia nervosa, bulimia nervosa or binge eating disorder.
• Women who are pregnant, lactating or trying to become pregnant.
• Currently taking any prescription medication for less than 3 months.
• Currently consuming >14 alcoholic drinks (1 drink = 12 fl oz beer, 4 fl oz wine or 1.5 fl oz liquor) per week and/or unwilling to limit intake to less than 3 drinks per week during study participation.
• Known allergy to HFCS, sucrose, fructose or glucose.
• History of alcohol dependency
• Participation in another clinical trial within 30 days prior to enrollment.
• Lactose intolerance
• Currently smoking cigarettes
• Any clinically significant food allergy

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Rippe Lifestyle Institute

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Rippe Lifestyle Institute

Celebration, Florida, United States

Countries

United States

Other Identifiers

20131024

Identifier Type: -

Identifier Source: org_study_id