The Metabolic Effects of Consuming Sugar-Sweetened Beverages for Two Weeks

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

214 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-10-31

Study Completion Date

2014-01-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to examine the effects of consumption of sugar-sweetened beverages on blood triglycerides and cholesterol, cholesterol concentrations, and the body's sensitivity to insulin.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effects of Consuming Sugar-Sweetened Beverages With Meals for 10 Weeks

NCT01165853

Metabolic Syndrome Insulin Resistance Dyslipidemia

COMPLETED NA

Adverse Metabolic Effects of Dietary Sugar

NCT02548767

Chronic Disease of Cardiovascular System Type 2 Diabetes Obesity

COMPLETED NA

Effects of Sugar Sweetened Beverage on Metabolic Health in Male and Female Adolescents

NCT02058914

Insulin Sensitivity Insulin Tolerance

COMPLETED NA

Preliminary Effect of Food Processing and Sweeteners on Glycemic and Metabolic Measures

NCT05658757

Blood Sugar; High Blood Pressure Dietary Habits

COMPLETED NA

Short-term Sugary Beverage Consumption on Glucose Control and Cardiovascular Disease Risk Factors

NCT04118257

Metabolic Syndrome

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The study is designed as a prospective, blinded diet intervention study during which the participants consume either fructose- or HFCS-sweetened beverages (providing 10%, 17.5% or 25% of energy) with meals. In addition, there will be two control groups, with one group consuming 0% sugar beverages sweetened with sucralose and the other consuming glucose-sweetened beverages at 25% of energy requirement. Experimental procedures, including 24-hour serial blood sampling, post-heparin infusions, gluteal biopsies, Magnetic Resonance Imaging of the liver and the abdomen, and Oral Glucose Tolerance and Disposal Tests, are performed during baseline and at the end of a 2-week intervention period at the UC Davis Clinical and Translational Science Center (CTSC) Clinical Research Center (CCRC). During the inpatient periods, subjects are served energy balanced diets. The diets provide 15% of energy as protein, 30% as fat, and 55% as carbohydrate. During baseline testing, the carbohydrate content consists primarily of complex carbohydrate (\>97%). During intervention the 55% carbohydrate will consist of 10% sugar/45% complex, 17.5% sugar/37.5% complex, or 25% sugar/30% complex depending on the diet group to which the subject is assigned. During the outpatient intervention periods, the subjects reside at home and are provided with fructose- or HFCS -sweetened beverages that are consumed with each meal along with a self-selected ad libitum (usual) diet.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Metabolic Syndrome Insulin Resistance Dyslipidemia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Glucose

Group Type OTHER

Glucose

Intervention Type OTHER

25% dose at 2-week intervention assigned to subjects.

Fructose

Group Type OTHER

Fructose

Intervention Type OTHER

25%, 17.5%, or 10% dose at 2-week intervention assigned to subjects.

High-Fructose Corn Syrup

Group Type OTHER

High-Fructose Corn Syrup

Intervention Type OTHER

25%, 17.5%, or 10% dose at 2-week intervention assigned to subjects.

Aspartame

No sugar

Group Type OTHER

No sugar (Aspartame)

Intervention Type OTHER

0% dose at 2-week intervention assigned to subjects.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Glucose

25% dose at 2-week intervention assigned to subjects.

Intervention Type OTHER

Fructose

25%, 17.5%, or 10% dose at 2-week intervention assigned to subjects.

Intervention Type OTHER

High-Fructose Corn Syrup

25%, 17.5%, or 10% dose at 2-week intervention assigned to subjects.

Intervention Type OTHER

No sugar (Aspartame)

0% dose at 2-week intervention assigned to subjects.

Intervention Type OTHER

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Sugar Sugar HFCS Non-caloric sweetener

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Body mass index between 18-35
* Self report of stable body weight during the past six months

Exclusion Criteria

* Diabetes Mellitus
* Evidence of liver disorder
* Evidence of kidney disorder
* Evidence of thyroid disorder
* Systolic blood pressure consistently over 160mmHg or diastolic blood pressure over 900mmHg
* Triglycerides \> 400mg/dl
* LDL-C \> 240mg/dl
* Hemoglobin \< 8.5 g/dl
* Current, prior (within 2 months), or anticipated use of any hypolipidemic or anti-diabetic agents
* Use of Selective Serotonin Reuptake Inhibitors and anti-hypertensive medications
* Any other condition that, in the opinion of the investigators, would put subject at risk
* Strenuous exerciser
* Pregnant or lactating women
* Smoker
* Diet exclusions: food allergies, special dietary restrictions, habitual ingest of \>2 alcoholic beverages/day

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes