Sugar Sweetened Beverages (SSB)- Effects on Metabolism

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

96 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-04-30

Study Completion Date

2016-05-31

Brief Summary

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The objective of this study is to investigate the impact of sugar sweetened beverages on the fat metabolism of healthy young men. It is well known that consumption of beverages sweetened with fructose is associated with different health risks such as type 2 diabetes. The present study has been designed to dissect differences in the metabolic pathways of fructose and glucose, but also metabolic adaptations during fructose, glucose and sucrose diets. During a period of seven weeks subjects will consume either fructose, glucose or sucrose sweetened beverages or continue their usual drinking habits. During these seven weeks there will be different metabolic investigations using stable isotope tracers. First, the rate of lipolysis and beta-oxidation will be determined. Second, the rates of fatty acid synthesis will be measured. During all examinations there will also be substrate- and energy-utilization measurements by indirect calorimetry, blood analysis and morphometric measurements. Based on the literature main hypotheses are: Fructose enhances de novo lipogenesis postprandially and also in the fasting state significantly more than glucose by enhanced expression of lipogenic enzymes. Fructose decreases beta oxidation via downregulation of oxidative enzymes.

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Detailed Description

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Conditions

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Metabolism

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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fructose sweetened beverage

Soft drink consumption:

Subjects have to drink a fructose sweetened beverage (3x 200ml per day, 13.3g fructose/100ml) during 7 weeks

Group Type EXPERIMENTAL

Soft drink consumption

Intervention Type PROCEDURE

glucose sweetened beverage

Soft drink consumption:

Subjects have to drink a glucose sweetened beverage (3x 200ml per day, 13.3g glucose/100ml) during 7 weeks

Group Type EXPERIMENTAL

Soft drink consumption

Intervention Type PROCEDURE

sucrose sweetened beverage

Soft drink consumption:

Subjects have to drink a sucrose sweetened beverage (3x 200ml per day, 13.3g sucrose/100ml) during 7 weeks

Group Type EXPERIMENTAL

Soft drink consumption

Intervention Type PROCEDURE

No change of eating habits

No Soft drink consumption (no soft drink diet):

Subjects do not change their eating habits during 7 weeks

Group Type EXPERIMENTAL

Soft drink consumption

Intervention Type PROCEDURE

Interventions

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Soft drink consumption

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Healthy male volunteers aged 18-30
* BMI between 19-24 kg/m2
* Non-smoker

Exclusion Criteria

* Acute or chronic infections, malignant disease, renal, hepatic (more than two-fold increased transaminases), pulmonary, neurological (epilepsy) or psychiatric diseases, manifested atherosclerosis, or any other disease precluding participation in the study.
* Diabetes
* Known alcohol, substance or drug abuse, concomitant medication
* More than three hours of physical exercise per week
* Consumption of more than 2 times 3 dl SSB daily
* Subjects likely to fail to comply with the study protocol
* Subjects who do not give informed consent

Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No