Fructose Extra-splanchnic Metabolism and Its Effects on Systemic Flux of Substrates (FruPP)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

9 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-03-23

Study Completion Date

2018-08-31

Brief Summary

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In parallel to the dramatic rise in metabolic diseases and diabetes observed over the past fifty years, the generalization of added sugar in processed food led to a marked increase in fructose consumption in almost all countries, and epidemiological studies demonstrated that the consumption of sugar-sweetened beverage (containing at least 50% of fructose) is associated with the development of diabetes, hepatic steatosis, dyslipidemia and obesity.

The objective of the study is to measure the amount of fructose that escape first-pass hepatic extraction after oral ingestion (fructose+glucose), and gain insights into its metabolic fates with the use of tracers.

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Detailed Description

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Conditions

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Test Meal

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Test meal

The subjects will receive a liquid test meal containing glucose and fructose with 13C fructose.

Group Type EXPERIMENTAL

Test meal

Intervention Type OTHER

Liquid test meal (fructose+glucose)

Interventions

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Test meal

Liquid test meal (fructose+glucose)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Aged from 18 to 40 years
* Body Mass Index of 18.5 to 25 kg/m²
* Sex male of female

Exclusion Criteria

* Fructose intolerance
* Antidiabetic and hypolipemic drugs
* Alcohol consumption \>10g/day
* Severe eating disorders
* Severe psychological problems
* Vegetarian diet or other specific diet
* Consumption of illicit substances
* Pregnancy
* Weight gain or weight loss \> 3 kg in the last 3 months

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes