Effects of Monosodium Glutamate on Energy Balance and Eating Behavior

NCT ID: NCT01410838

Last Updated: 2015-05-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

44 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-08-31

Study Completion Date

2014-08-31

Brief Summary

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This study will test whether regular consumption of Monosodium Glutamate (MSG) immediately prior to each of the three major meals (breakfast, lunch, dinner) inhibits body weight and fat regain following a period of moderate, yet clinically significant weight loss.

Detailed Description

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The proposed study enables us to assess the long term effects of consuming MSG on body weight regain following weight loss.

Conditions

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Obesity Weight Gain Food Preferences

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Broth- NaCl

Sodium chloride containing broth matched for sodium content to the MSG broth

Group Type PLACEBO_COMPARATOR

Broth

Intervention Type OTHER

200 mL of sodium chloride containing broth, consumed three times per day

Broth- MSG

MSG containing broth with the same sodium content as the placebo comparator.

Group Type ACTIVE_COMPARATOR

Broth

Intervention Type OTHER

200 mL of MSG containing broth consumed three times per day

Interventions

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Broth

200 mL of sodium chloride containing broth, consumed three times per day

Intervention Type OTHER

Broth

200 mL of MSG containing broth consumed three times per day

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Women
* Age 19-45
* BMI 27-35
* Blood pressure \<140/90
* Non-smoking

Exclusion Criteria

* Anemic: hgb \< 11.5 mg/dL
* Sensitivity to MSG (self reported)
* Pregnant or planning to get pregnant
* Taking medication for hypertension, depression, or weight loss
* Diabetic
* Vegetarian
* MRI Contraindications: internal metal, braces on teeth, history of metal in the eye, claustrophobia
* blindness or heavily corrected vision
* not fluent in English
Minimum Eligible Age

19 Years

Maximum Eligible Age

50 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Ajinomoto USA, INC.

INDUSTRY

Sponsor Role collaborator

USDA, Western Human Nutrition Research Center

FED

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kevin Laugero, PhD

Role: PRINCIPAL_INVESTIGATOR

WHNRC, ARS, University of California Davis

Locations

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Western Human Nutrition Center, University of California Davis

Davis, California, United States

Site Status

Countries

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United States

Related Links

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http://www.ars.usda.gov/Main/docs.htm?docid=11240

USDA Western Human Nutrition Research Center

Other Identifiers

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WHNRC 222718-2

Identifier Type: -

Identifier Source: org_study_id

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