Repeated Exposure to Umami Taste on Taste Perception, Hedonics, and Satiety

NCT ID: NCT03010930

Last Updated: 2022-02-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

64 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-10-31

Study Completion Date

2016-11-30

Brief Summary

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The purpose of this study is to determine how repeated dietary exposure to umami taste affects umami taste perception, hedonics, food preferences, and satiety. Healthy adult subjects will consume a low glutamate vegetable broth daily for one month, where the experimental group's broth is supplemented with the umami-rich stimuli of monosodium glutamate (MSG) and the control group's low glutamate broth is matched for sodium (NaCl).

The investigators hypothesize that repeated dietary exposure to umami taste will:

1. diminish umami suprathreshold intensity perception and hinder the ability to discriminate varying MSG concentrations
2. decrease liking of umami-rich foods and shift preferences upwards towards more intense umami stimuli
3. decrease satiation and decrease the satiating effect of a test meal

Detailed Description

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Conditions

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Umami Taste Perception

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Increased exposure to MSG

Subjects consume vegetable broth daily containing MSG

Group Type EXPERIMENTAL

Supplementation of diet with MSG

Intervention Type OTHER

Subjects eat normal diet and consume 8 ounces of vegetable broth with added MSG one time per day for 1 month

No change in exposure to MSG

Subjects consume low glutamate vegetable broth daily, sodium-matched to the broth of the experimental group with NaCl

Group Type SHAM_COMPARATOR

No supplementation of diet with MSG

Intervention Type OTHER

Subjects eat normal diet and consume 8 ounces of low glutamate vegetable broth without MSG (sodium-matched with NaCl) one time per day for 1 month

Interventions

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Supplementation of diet with MSG

Subjects eat normal diet and consume 8 ounces of vegetable broth with added MSG one time per day for 1 month

Intervention Type OTHER

No supplementation of diet with MSG

Subjects eat normal diet and consume 8 ounces of low glutamate vegetable broth without MSG (sodium-matched with NaCl) one time per day for 1 month

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Have normal sense of taste and smell (self-report)
* Likes soups or broths (self-report)
* Able to report to study site daily (self-report)

Exclusion Criteria

* Restrained eater (score \> 12 on restrained eating subscale from Three Factor Eating Questionnaire)
* BMI \< 18 or \> 25 kg/m2 (self-report)
* Vegan (self-report)
* Hypertensive or on low-sodium diet (self-report)
* Allergic or sensitive to MSG (self-report)
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cornell University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

References

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Noel CA, Finlayson G, Dando R. Prolonged Exposure to Monosodium Glutamate in Healthy Young Adults Decreases Perceived Umami Taste and Diminishes Appetite for Savory Foods. J Nutr. 2018 Jun 1;148(6):980-988. doi: 10.1093/jn/nxy055.

Reference Type DERIVED
PMID: 29796671 (View on PubMed)

Other Identifiers

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1608006563

Identifier Type: -

Identifier Source: org_study_id

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