Taste Physiology in Healthy, Normal-weight Volunteers

NCT ID: NCT02255812

Last Updated: 2014-10-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-03-31

Study Completion Date

2013-10-31

Brief Summary

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Taste physiology describes five main taste qualities in humans: sweet, sour, salty, umami and bitter. The receptors found on the tongue are also found in the entire gut. The correlation of stimulation of these gut receptors and brain activity has not yet been examined. The objectives are to investigate the effect of different taste substances on i) regional brain activity and ii) satiation peptide release.

Detailed Description

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Conditions

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Exploratory Behavior

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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200 mL tap water

Single intragastric instillation of 200 mL tap water via nasogastric tube

Group Type PLACEBO_COMPARATOR

Single intragastric instillation of 200 mL tap water via nasogastric tube

Intervention Type DIETARY_SUPPLEMENT

2 g citric acid

Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube

Group Type ACTIVE_COMPARATOR

Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube

Intervention Type DIETARY_SUPPLEMENT

2 g salt

Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube

Group Type ACTIVE_COMPARATOR

Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube

Intervention Type DIETARY_SUPPLEMENT

0.017 g quinine

Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tube

Group Type ACTIVE_COMPARATOR

Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tube

Intervention Type DIETARY_SUPPLEMENT

1 g monosodium glutamate

Single intragastric instillation of 1 g monosodium glutamate in 200 mL tap water via nasogastric tube

Group Type ACTIVE_COMPARATOR

Single intragastric instillation of 1 g monosodium glutamate in 200 mL tap water via nasogastric tube

Intervention Type DIETARY_SUPPLEMENT

25 g glucose

Single intragastric instillation of 25 g glucose in 200 mL tap water via nasogastric tube

Group Type ACTIVE_COMPARATOR

Single intragastric instillation of 25 g glucose in 200 mL tap water via nasogastric tube

Intervention Type DIETARY_SUPPLEMENT

Interventions

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Single intragastric instillation of 200 mL tap water via nasogastric tube

Intervention Type DIETARY_SUPPLEMENT

Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube

Intervention Type DIETARY_SUPPLEMENT

Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube

Intervention Type DIETARY_SUPPLEMENT

Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tube

Intervention Type DIETARY_SUPPLEMENT

Single intragastric instillation of 1 g monosodium glutamate in 200 mL tap water via nasogastric tube

Intervention Type DIETARY_SUPPLEMENT

Single intragastric instillation of 25 g glucose in 200 mL tap water via nasogastric tube

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* right-handed healthy males
* Body-mass index of \< 25
* Age 18-45 years
* no drugs
* non-smoking

Exclusion Criteria

* Smoking
* Substance abuse
* Regular intake of medications (except for oral contraceptives)
* Medical or psychiatric illness, especially: diabetes, pace-maker, claustrophobia
* History of gastrointestinal disorders
* Food allergies, glutamate intolerance
* Body piercings that cannot be removed
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Basel, Switzerland

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Christoph Beglinger, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Basel, Switzerland

Locations

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University Hospital

Basel, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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EKBB 289/12/2

Identifier Type: -

Identifier Source: org_study_id

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