Effect of Different Liquids Intake in Vasovagal Reaction After Whole Blood Donation

NCT ID: NCT05319951

Last Updated: 2022-10-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

6250 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-20

Study Completion Date

2021-12-31

Brief Summary

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we compared the effect of 3 different kinds of liquids (water, Oral Rehydration Salt 3 and white granulated sugar water) intake in Vasovagal Reaction After Whole Blood Donation

Detailed Description

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Vasovagal reaction is the most common type of blood donation reaction. The main cause of this reaction is the decrease of blood volume. Therefore, fluid supplement before blood donation has been proved to be effective in preventing the vagal reaction after blood donation. It was proved that isotonic (sugar \& salt) drink intake before blood donation had a significant effect on reducing vasovagal reaction.

However, in 2002, WHO recommended the new reduced osmolarity rehydration formula with better taste. Oral Rehydration Salt 3 has been produced according to WHO formula with standard ingredient and easy to prepare. In addition, in Guangdong culture, sugar water is regarded as a tonic, more easily accepted. So, the aim of our study was to compare the effects of 500 ml water with Oral Rehydration Salt 3, white granulated sugar and conventional recommended water intake prior to blood donation on blood donation reaction after whole blood donation, in order to understand the effect of different liquid supplement on blood donation reaction and the willingness of blood donation again.

Conditions

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Blood Donation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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Oral Rehydration Salts Power (iii)

Dissolve 2 packs of Oral Rehydration Salts Power (iii) (5.125g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.

Group Type EXPERIMENTAL

Oral Rehydration Salts power (iii)

Intervention Type DRUG

Dissolve 2 packs of Oral Rehydration Salts Power (iii) (5.125g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.

water with white granulated sugar

Dissolve 2 packs of Taikoo white granulated sugar (5g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.

Group Type EXPERIMENTAL

water with white granulated sugar

Intervention Type DIETARY_SUPPLEMENT

Dissolve 2 packs of Taikoo white granulated sugar (5g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.

recommended water intake

Recommend the subjects to drink up 500ml water in 20 minutes prior to donation.

Group Type PLACEBO_COMPARATOR

water

Intervention Type DIETARY_SUPPLEMENT

Recommend the subjects to drink up 500ml water in 20 minutes prior to donation.

Interventions

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Oral Rehydration Salts power (iii)

Dissolve 2 packs of Oral Rehydration Salts Power (iii) (5.125g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.

Intervention Type DRUG

water with white granulated sugar

Dissolve 2 packs of Taikoo white granulated sugar (5g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.

Intervention Type DIETARY_SUPPLEMENT

water

Recommend the subjects to drink up 500ml water in 20 minutes prior to donation.

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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Sichuan Emeishan Pharmaceutical Co., Ltd. 20210402 5100621103491

Eligibility Criteria

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Inclusion Criteria

\-

Exclusion Criteria

\-
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Guangzhou Blood Center

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Guiyun Xie, MPH

Role: STUDY_CHAIR

Guangzhou Blood Center

Jinyan Chen, MPH

Role: PRINCIPAL_INVESTIGATOR

Guangzhou Blood Center

Shijie Li

Role: STUDY_DIRECTOR

Guangzhou Blood Center

Locations

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Guangzhou Blood Center

Guangzhou, Guangdong, China

Site Status

Countries

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China

Other Identifiers

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Different liquids intake

Identifier Type: -

Identifier Source: org_study_id

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