Effect of Amino Acid Addition to a Drink on the Appearance of Ingested Water in Body Fluids1

NCT ID: NCT04819334

Last Updated: 2025-02-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-02-12

Study Completion Date

2021-05-01

Brief Summary

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To determine the effects of a moderate amount of amino acids on the rate of water absorption and availability as a precursor fluid for sweat. Young and healthy (male or female) volunteers will take part in three experimental trials. In each trial, volunteers will be given one of two commercially available sports drinks or a commercially available sport drink with added amino acids in a double-blinded, randomised, crossover design. Each drink will be a single 600 mL bolus. All beverages will be labelled with deuterium (D2O). Trials will be compared for temporal accumulation of deuterium in plasma over the course of 60 minutes. Whole blood measurements of haemoglobin and haematocrit will also be made and plasma volume changes calculated. It is hypothesised that the amino acid trial will increase the rate of fluid absorption.

Detailed Description

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Conditions

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Rate of Water Appearance/Delivery in the Blood Water Balance

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Double-blind, randomised, crossover design
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators
Double-blind

Study Groups

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Commercially Available Sports Drink A

A commercially available flavored electrolyte solution, The Coca-Cola Company

Group Type PLACEBO_COMPARATOR

Composition of Sports Drink

Intervention Type OTHER

The composition of sport drinks will be manipulated to determine the effect of drink composition on the appearance of ingested water in body fluid.

Commercially Available Sports Drink B

A commercially available flavored electrolyte solution, PepsiCo

Group Type EXPERIMENTAL

Composition of Sports Drink

Intervention Type OTHER

The composition of sport drinks will be manipulated to determine the effect of drink composition on the appearance of ingested water in body fluid.

Commercially Available Sports Drink A with added Amino Acids

he same as sports drink A above (a commercially available flavored electrolyte solution, The Coca-Cola Company), but with the addition of a small amount of amino acids (\~2.6 g/100 ml).

Group Type EXPERIMENTAL

Composition of Sports Drink

Intervention Type OTHER

The composition of sport drinks will be manipulated to determine the effect of drink composition on the appearance of ingested water in body fluid.

Interventions

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Composition of Sports Drink

The composition of sport drinks will be manipulated to determine the effect of drink composition on the appearance of ingested water in body fluid.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Generally fit and healthy (determined by health screen questionnaire)
* Recreationally active (minimum 3 hours of physical activity per week including walking)

Exclusion Criteria

* Any cardiovascular, gastrointestinal, renal or acute/chronic health conditions that may influence the outcomes
* Smoking (including vaping)
* BMI of greater than 30 (combined with a body fat percentage greater than 20%) or BMI lower than 17.5
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Entrinsic Beverage Company LLC

UNKNOWN

Sponsor Role collaborator

Loughborough University

OTHER

Sponsor Role lead

Responsible Party

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Lewis James

Senior Lecturer in Nutrition

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Loughborough University

Loughborough, Leicestershire, United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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LEON3151

Identifier Type: -

Identifier Source: org_study_id

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