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Influence of Intragastric Fructose Infusion on Behavioural and Neural Responses to Negative Emotion Induction

NCT ID: NCT02946983

Last Updated: 2016-10-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-09-30

Study Completion Date

2016-06-30

Brief Summary

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The investigators will test whether a subliminal, intragastric dose of fructose is able to influence the emotional state at the behavioural and neural level, as has been previously shown for fatty acids. They will also examine the potential involvement of gut peptide release. Based on previous research using fatty acids, an attenuating effect of fructose compared to placebo on the induced negative emotional state is hypothesized at the self-report as well as the brain level.

Detailed Description

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Conditions

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Healthy Volunteers

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Fructose - Neutral emotion condition

Intragastric infusion of fructose with neutral emotion induction

Group Type ACTIVE_COMPARATOR

Fructose

Intervention Type OTHER

Intragastric administration of fructose (25g dissolved in 250ml distilled water)

Fructose - Sad emotion condition

Intragastric infusion of fructose with sad emotion induction

Group Type ACTIVE_COMPARATOR

Fructose

Intervention Type OTHER

Intragastric administration of fructose (25g dissolved in 250ml distilled water)

Placebo - Neutral emotion condition

Intragastric infusion of distilled water with neutral emotion induction

Group Type PLACEBO_COMPARATOR

Control

Intervention Type OTHER

Intragastric administration of distilled water

Placebo - Sad emotion condition

Intragastric infusion of distilled water with sad emotion induction

Group Type PLACEBO_COMPARATOR

Control

Intervention Type OTHER

Intragastric administration of distilled water

Interventions

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Fructose

Intragastric administration of fructose (25g dissolved in 250ml distilled water)

Intervention Type OTHER

Control

Intragastric administration of distilled water

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy volunteers (N=15)
* Male and female
* Age 18 - 60
* Body Mass Index (BMI) of 20 - 25 kg/m2
* Stable body weight for at least 3 months prior to the start of the study

Exclusion Criteria

* Abdominal or thoracic surgery. Exception: appendectomy
* Gastrointestinal, endocrine or neurological diseases. Exception: IBS if the participant will be recruited in the patient group
* Cardiovascular, respiratory, renal or urinary diseases
* Hypertension
* Food or drug allergies
* Anemia
* Eating disorders
* Psychotic disorders
* Depressive disorders
* Emotional and/or restraint eating
* No medication on a regular basis, exception: oral contraception
* No history of cannabis use or any other drug of abuse for at least 12 months prior to the study
* Alcohol abuse (more than 21 units of alcohol for men, more than 14 units for woman per week)
* Conditions that can interfere with functional magnetic resonance imaging (fMRI), e.g. cochlear implants, metal fragments or metal implants in the body, pacemaker, neural stimulator, …
* Pregnant or breastfeeding women
* Claustrophobia
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Universitaire Ziekenhuizen KU Leuven

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jan Tack, Prof

Role: PRINCIPAL_INVESTIGATOR

University of Leuven

References

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Iven J, Biesiekierski JR, Zhao D, Tack J, Van Oudenhove L. Intragastric fructose administration interacts with emotional state in homeostatic and hedonic brain regions. Nutr Neurosci. 2022 Mar;25(3):581-592. doi: 10.1080/1028415X.2020.1781326. Epub 2020 Jun 19.

Reference Type DERIVED
PMID: 32558624 (View on PubMed)

Other Identifiers

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S57996

Identifier Type: -

Identifier Source: org_study_id