The Effect of Dairy and Non-dairy Alternatives on Satiety and Post-meal Glycemia in Healthy Young Adults

NCT ID: NCT02491814

Last Updated: 2016-05-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-01-31

Study Completion Date

2015-06-30

Brief Summary

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This study investigates the effects of commercially-available dairy (1% cow's milk and yogurt beverage) and non-dairy alternatives (almond and soy beverages) on satiety and post-meal blood glucose. Each participant will receive every treatment in this crossover design study.

Detailed Description

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Regular consumption of dairy is associated with better body composition and lower incidences of type 2 diabetes and obesity. This may be due to dairy's ability to increase satiety and decrease post-prandial glycemia. However, most clinical studies have only investigated isolated dairy proteins (whey and casein) and the effects of whole dairy products remains unclear. Additionally, as non-dairy alternatives are becoming more popular there is interest to see if they can elicit similar benefits as dairy. Therefore, this study will test the effects of commercially-available dairy and non-dairy beverages when consumed with cereal at breakfast time.

Thirty healthy young males and females (20-30 years, BMI 20.0-24.9 kg/m2) will be recruited for the randomized, unblinded, crossover study. Participants will fast overnight, and at baseline will consume 250 mL of 1% milk, soy beverage, almond beverage, yogurt beverage, or water with 54 g of Cheerios cereal. At 0 (baseline), 15, 30, 45, 60, 75, 90, 120 minutes (pre-meal period) 140, and 170 minutes (post-meal period) blood will be collected for glucose analysis and subjective appetite ratings completed. Insulin will be analyzed every 30 minutes and for the last two timepoints. Between 120-140 minutes, an ad libitum lunch will be provided to assess food intake.

Conditions

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Diabetes Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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1% M.F. Milk and Breakfast Cereal

Breakfast meal: 250 ml 1% M.F. Milk, 54 g Cheerios breakfast cereal, 100 mL water

Group Type EXPERIMENTAL

1% M.F. Milk

Intervention Type OTHER

Breakfast cereal

Intervention Type OTHER

Yogurt Beverage and Breakfast Cereal

Breakfast meal: 250 ml Yogurt Beverage, 54 g Cheerios breakfast cereal, 100 mL water

Group Type EXPERIMENTAL

Yogurt Beverage

Intervention Type OTHER

Breakfast cereal

Intervention Type OTHER

Soy Beverage and Breakfast Cereal

Breakfast meal: 250 ml Soy Beverage, 54 g Cheerios breakfast cereal, 100 mL water

Group Type EXPERIMENTAL

Soy Beverage

Intervention Type OTHER

Breakfast cereal

Intervention Type OTHER

Almond Beverage and Breakfast Cereal

Breakfast meal: 250 ml Almond Beverage, 54 g Cheerios breakfast cereal, 100 mL water

Group Type EXPERIMENTAL

Almond Beverage

Intervention Type OTHER

Breakfast cereal

Intervention Type OTHER

Water (control) and Breakfast Cereal

Breakfast meal: 250 ml Water, 54 g Cheerios breakfast cereal, 100 mL water

Group Type EXPERIMENTAL

Water

Intervention Type OTHER

Breakfast cereal

Intervention Type OTHER

Interventions

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1% M.F. Milk

Intervention Type OTHER

Yogurt Beverage

Intervention Type OTHER

Soy Beverage

Intervention Type OTHER

Almond Beverage

Intervention Type OTHER

Water

Intervention Type OTHER

Breakfast cereal

Intervention Type OTHER

Other Intervention Names

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1% cow's milk Neilsen Canada Yop (Vanilla), General Mills Soy Milk Silk Organic Original Almond Milk Silk Original Calorie-free control Cheerios, General Mills

Eligibility Criteria

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Inclusion Criteria

* Healthy BMI (20.0 - 24.9 kg/m2)
* Females with regular monthly menstrual cycles

Exclusion Criteria

* Diabetes
* Fasting blood glucose higher than 5.8 mmol/L
* Pregnancy
* Medications
* Smoking
* Lactose intolerance or allergies to milk, soy, or almonds
* Elite athletes
* Those trying to lose or gain weight
* Breakfast skippers and those on an energy-restricted diet
* Score equal to or higher than 11 on Eating Habits Questionnaire
Minimum Eligible Age

20 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Dairy Farmers of Canada

OTHER

Sponsor Role collaborator

University of Toronto

OTHER

Sponsor Role lead

Responsible Party

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G. Harvey Anderson

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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G. Harvey Anderson, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Department of Nutritional Sciences, University of Toronto

Locations

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Department of Nutritional Sciences, FitzGerald Building

Toronto, Ontario, Canada

Site Status

Countries

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Canada

Other Identifiers

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DFC_31012

Identifier Type: -

Identifier Source: org_study_id

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