The Effect of Resistance Exercise on Inflammation in Young and Older Adults

NCT ID: NCT05042167

Last Updated: 2023-01-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-10-01

Study Completion Date

2022-12-31

Brief Summary

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Healthy young and older adults will complete two trials in a randomized crossover counter-balanced order, including resistance exercise and sedentary control. During each trial, blood samples will be collected.

The investigators hypothesized that an acute bout of resistance exercise exert different inflammation responses in young and older adults.

Detailed Description

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Conditions

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Aging Inflammatory Response

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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High-load resistance exercise

Subjects in high-load trial performed 3 sets per exercise, 8 repetitions with load of 70%-1RM with 90 sec of rest between sets, followed by a fourth set to voluntary failure.

Group Type EXPERIMENTAL

Resistance exercise

Intervention Type OTHER

4 total resistance exercises that target all major muscle groups.

Sedentary control

Subjects in control trial stayed sedentary during the period.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Resistance exercise

4 total resistance exercises that target all major muscle groups.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age: 20-80
* Healthy male
* Without experience of resistance training

Exclusion Criteria

* No acute or chronic musculoskeletal symptoms
* Smoking
* Alcohol or drug abuse
* Fail to conduct resistance exercise
Minimum Eligible Age

20 Years

Maximum Eligible Age

80 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Taiwan Normal University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hung-Wen Liu, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

National Taiwan Normal University

Locations

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National Taiwan Normal University

Taipei, , Taiwan

Site Status

Countries

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Taiwan

References

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Tsai SH, Cheng HC, Little JP, Islam H, Liu HW. Elevated Plasma IL-6 Coincides with Activation of STAT3 in PBMC After Acute Resistance Exercise. Med Sci Sports Exerc. 2024 Nov 1;56(11):2117-2124. doi: 10.1249/MSS.0000000000003503.

Reference Type DERIVED
PMID: 39475859 (View on PubMed)

Other Identifiers

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202012HM020

Identifier Type: -

Identifier Source: org_study_id

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