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Impact of Acute Exercise Intensity and Pattern on Cytokine Function

NCT ID: NCT05574413

Last Updated: 2023-12-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-09-15

Study Completion Date

2023-09-01

Brief Summary

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The immune system helps prevent illness, fights off infections, and repairs damaged tissues following an injury. However, when immune cells remain active for prolonged periods of time - a state known as "chronic inflammation" - they can contribute to the development and progression of chronic diseases like heart disease and diabetes. Exercise can reduce the risk of developing many of these diseases and at least part of the health benefits of exercise are due to the ability of exercise to reduce "chronic inflammation". The inflammation-lowering effects of exercise are typically captured by measuring hormone-like molecules released from immune cells called "cytokines" in the blood. In addition to changes in circulating cytokine levels, exercise may also alter how immune cells respond to these cytokines. How exercise intensity (i.e., how hard you are working during exercise) and pattern (i.e., exercising as a long continuous bout or in short intervals) impact the ability of immune cells to respond to cytokines is not well understood. A better understanding of how exercise intensity and pattern of exercise for reducing chronic inflammation may help determine the best types of exercises for improving health and preventing chronic diseases.

Detailed Description

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Conditions

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Inflammation

Keywords

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Exercise Cytokines Leukocytes Interleukin-10 Interleukin-6

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Repeated measures randomized counterbalanced crossover design
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Resting (no exercise) control

Resting (no exercise) control condition

Group Type PLACEBO_COMPARATOR

Resting (no exercise) control

Intervention Type OTHER

Participants will remain in a rested state (i.e., no exercise) for the entire session. Blood samples will be obtained at the same time-points as the exercise sessions.

Moderate intensity continuous exercise (MICE)

Experimental session involving an acute bout of moderate intensity continuous exercise (MICE; continous cycling expending 350 kcal at 70% of lactate threshold)

Group Type EXPERIMENTAL

Moderate intensity continuous exercise

Intervention Type OTHER

Participants will perform an acute bout of continuous cycling at 70% of the power output at lactate threshold until an energy expenditure of 350 kcal is achieved. Blood samples will be obtained immediately before and immediately, 30, and 90 minutes after exercise.

High intensity continuous exercise (HICE)

Experimental session involving an acute bout of high intensity continuous exercise (HICE; continuous cycling expending 350 kcal at 10% of the difference between lactate threshold and VO2peak)

Group Type EXPERIMENTAL

High intensity continuous exercise

Intervention Type OTHER

Participants will perform an acute bout of continuous cycling at 10% of the difference between lactate threshold and VO2peak until an energy expenditure of 350 kcal is achieved. Blood samples will be obtained immediately before and immediately, 30, and 90 minutes after exercise.

High intensity interval exercise (HIIT)

Experimental session involving an acute bout of high intensity interval exercise (HIIT; cycling intervals expending 350 kcal at 10% of the difference between lactate threshold and VO2peak)

Group Type EXPERIMENTAL

High intensity interval exercise

Intervention Type OTHER

Participants will perform an acute bout of interval cycling at at 10% of the difference between lactate threshold and VO2peak until an energy expenditure of 350 kcal is achieved. Blood samples will be obtained immediately before and immediately, 30, and 90 minutes after exercise.

Interventions

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Moderate intensity continuous exercise

Participants will perform an acute bout of continuous cycling at 70% of the power output at lactate threshold until an energy expenditure of 350 kcal is achieved. Blood samples will be obtained immediately before and immediately, 30, and 90 minutes after exercise.

Intervention Type OTHER

High intensity continuous exercise

Participants will perform an acute bout of continuous cycling at 10% of the difference between lactate threshold and VO2peak until an energy expenditure of 350 kcal is achieved. Blood samples will be obtained immediately before and immediately, 30, and 90 minutes after exercise.

Intervention Type OTHER

High intensity interval exercise

Participants will perform an acute bout of interval cycling at at 10% of the difference between lactate threshold and VO2peak until an energy expenditure of 350 kcal is achieved. Blood samples will be obtained immediately before and immediately, 30, and 90 minutes after exercise.

Intervention Type OTHER

Resting (no exercise) control

Participants will remain in a rested state (i.e., no exercise) for the entire session. Blood samples will be obtained at the same time-points as the exercise sessions.

Intervention Type OTHER

Other Intervention Names

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MICE HICE HIIE CTL

Eligibility Criteria

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Inclusion Criteria

* 18-35 years of age
* Body mass index between 18.5-30 kg/m\^2
* Free of cardiometabolic and autoimmune/inflammatory disease

Exclusion Criteria

* Competitive endurance athlete
* Cigarette smoker
* Currently taking immunomodulatory/anti-inflammatory medications
* Currently pregnant
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of British Columbia

OTHER

Sponsor Role lead

Responsible Party

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Jonathan Little

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jonathan P Little, PhD

Role: PRINCIPAL_INVESTIGATOR

UBC Okanagan

Locations

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UBC Okanagan

Kelowna, British Columbia, Canada

Site Status

Countries

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Canada

Other Identifiers

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AEX2022

Identifier Type: -

Identifier Source: org_study_id