The Effect of Exercise Training in the Community-dwelling Adults With Chronic Disorders

NCT ID: NCT02017067

Last Updated: 2013-12-20

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 58 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2012-04-30
• Study Completion Date: 2013-09-30

Brief Summary

Previous studies have demonstrated that resistance training (RT) is beneficial to increase muscle strength, improve functional ability and the ability to rapidly produce force, known as the contractile rate of force development (RFD) in older adults. However, much less research has focused on the effect of RT on the lower extremity muscle strength, contractile RFD and impulse in middle-aged and older people with musculoskeletal conditions, especially for osteoporosis (OP) (or osteopenia) or knee osteoarthritis (KOA). Therefore, the purpose of this study was to investigate the effect of RT on the lower extremity muscle strength, RFD and impulse in middle-aged and older people with musculoskeletal conditions, especially for OP and knee OA (KOA). The investigators hypothesized that such a training program would lead to induce not only specific muscle strength enhancement but also an increment in contractile RFD and impulse.

Detailed Description

Osteoporosis (OP) and osteoarthritis (OA) are the two most common musculoskeletal conditions in older adults, causing high healthcare costs and negative effects on quality of life. Previous studies have reported that OP and OA has a strong association with sarcopenia, a term defined as age-related involuntary loss of skeletal muscle mass and strength or function.A decline of muscle mass and strength in older adults may limit a variety of activities of daily living (ADLs) and increase morbidity and mortality. However, many ADLs often involve faster limb movements with contraction times of 50 - 200 ms (i.e. sit-to-stand performance and avoiding falls). Therefore, in addition to muscle mass and strength, the ability to rapidly produce force, known as the contractile rate of force development (RFD), and the area under the force-time curve, defined as contractile impulse, seem to be important to adequately characterize the performance of ADLs in older adults. Typically, resistance training (RT) is often prescribed to increase muscle strength, improve functional ability and eliminate much of age-associated muscle atrophy and weakness in a healthy population. Other studies have also shown that implementation of RT can help improve RFD in healthy young and elderly individuals following RT. However, it still unclear that the effect of RT on contractile RFD and impulse in middle-aged and older people with musculoskeletal conditions. Therefore, the aim of this study was to examine the effects on the lower extremity muscle strength, contractile rate of force development (RFD), impulse in middle-aged and older people with osteoporosis (OP)(or osteopenia) or knee osteoarthritis (KOA) after 12 weeks of resistance training.

Conditions

Osteoporosis; Osteoarthritis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: HEALTH_SERVICES_RESEARCH
• Blinding Strategy: NONE

Study Groups

control

Maintain regular physical activity as usual, and received health education material about their disease, importance of nutrition and risks factors.

Group Type: NO_INTERVENTION

No interventions assigned to this group

hydraulic resistance circuit training

12 weeks resistance training

Group Type: EXPERIMENTAL

hydraulic resistance circuit training

Intervention Type: PROCEDURE

12 weeks (3 times per week, 40 min circuit) of hydraulic resistance circuit training that consisted of 7 types of equipments for different part of strength training.

Interventions

hydraulic resistance circuit training

12 weeks (3 times per week, 40 min circuit) of hydraulic resistance circuit training that consisted of 7 types of equipments for different part of strength training.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

(1) 45 years old or older; (2) diagnosed by a physician with osteoporosis (or osteopenia) or/and osteoarthritis; (3) able to participate safely in a moderately vigorous program of physical activity; (4) not previously taken part in any type of resistance training but were all physically capable of entering exercise.

Exclusion Criteria

(1) a acute or terminal illness, myocardial infarction within 6 months (or other symptomatic coronary artery disease); (2) uncontrolled hypertension (> 150/90 mmHg); (3) fracture in the previous 6 months; (3) diseases or medication affecting neuromuscular function; (4) physical limitation in sports and were advised not to exercise by doctors.

• Minimum Eligible Age: 45 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Far Eastern Memorial Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Tsung-Ching Lin, Master

Role: STUDY_CHAIR

Far Eastern Memorial Hospital

Locations

Tsung-Ching Lin

New Taipei City, Taiwan, Taiwan

Countries

Taiwan

Other Identifiers

FEMH-IRB-101020-E

Identifier Type: -

Identifier Source: org_study_id