The Effects of Age on Muscle Endurance During Resistance Exercise With and Without Blood Flow Restriction

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-30

Study Completion Date

2026-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to learn how aging affects muscle endurance during resistance exercise, and how oxygen delivery to the muscles plays a role in these changes. To answer this question, we are comparing how many repetitions of a leg exercise (knee extensions) younger and older adults can do at different exercise intensities. We will also look at how the muscles use oxygen during these exercises.

Participants will take part in 12 different exercise sessions. In each session, they will perform as many knee extensions as possible using different amounts of weight-consisting of 20%, 30%, 40%, 50%, 60% and 70% of the maximum weight they can lift one time. Each weight will be tested both with and without a cuff on the leg that temporarily reduces blood flow to the muscle.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Comparing Vascular Responses to Resistance Exercise with and Without Blood Flow Restriction in Young and Older Adults

NCT06596304

Ageing Blood Flow Restriction

RECRUITING NA

Blood Flow Restriction and Functionality in Older Adults

NCT06724393

Older Adults (65 Years and Older) Older Adults At Risk of Falling Blood Flow Restriction (BFR) Training Effects +1 more

ENROLLING_BY_INVITATION NA

Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men

NCT02842593

Weight-Lifting Exercise Program

COMPLETED NA

The Effect of Exercise on Myokine Production in Aging Persons

NCT05571709

Aging Exercise

UNKNOWN NA

Upper- and Lower-body Resistance Exercise With and Without Blood Flow Restriction on Hemodynamics and Vascular Function

NCT03225898

Endothelial Dysfunction Autonomic Dysfunction

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Ageing Muscle Fatigue Caused by Repetitive Muscle Exercise

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Young cohort

Young, healthy participants aged 19-35 will perform maximum repetitions of knee extension exercise at 20%, 30%, 40%, 50%, 60% and 70% of their one rep max with and without blood flow occlusion.

Group Type EXPERIMENTAL

Knee extension exercise

Intervention Type OTHER

Maximum repetitions of knee extension exercise at 20%, 30%, 40%, 50%, 60% and 70% of participants one rep max with and without blood flow occlusion

Older cohort

Older, healthy participants aged 65 years and up will perform maximum repetitions of knee extension exercise at 20%, 30%, 40%, 50%, 60% and 70% of their one rep max with and without blood flow occlusion.

Group Type EXPERIMENTAL

Knee extension exercise

Intervention Type OTHER

Maximum repetitions of knee extension exercise at 20%, 30%, 40%, 50%, 60% and 70% of participants one rep max with and without blood flow occlusion

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Knee extension exercise

Maximum repetitions of knee extension exercise at 20%, 30%, 40%, 50%, 60% and 70% of participants one rep max with and without blood flow occlusion

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Able to understand and communicate in English
* 19-35 years of age
* 65 years of age or older
* All "No" answers on the CSEP Get Active questionnaire or doctors' approval to participate

Exclusion Criteria

* BMI lower than 18 or greater than 32
* Current use of cigarettes or other nicotine devices
* Any major uncontrolled cardiovascular, muscular, metabolic, and/or neurological disorders
* Any medical condition impacting the ability to participate in maximal exercise
* Type one or type two diabetes
* Diagnosis of cancer or undergoing cancer treatment in the past 12 months
* Taking blood-thinning medication or the presence of a bleeding disorder
* Drug therapy with any drugs that alter skeletal muscle metabolism (i.e., Metformin, Benzodiazepines)
* Lowest calculated exercise testing load is less than the lightest weight able to be provided by the lab gymnasium equipment
* In the past six months, completing more than 300 minutes of moderate physical activity or 150 minutes of vigorous physical activity per week
* In the past six months, completing less than 150 minutes of moderate physical activity or 75 minutes of vigorous physical activity

Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes