Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men

NCT ID: NCT02842593

Last Updated: 2017-01-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-09-30

Study Completion Date

2016-08-31

Brief Summary

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This study evaluates the effects of two types of resistance exercise training (higher-repetition, lower load vs lower-repetition, higher load vs control) on regional and local measures of arterial stiffness in trained young men.

Detailed Description

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Conditions

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Weight-Lifting Exercise Program

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Resistance exercise training

Whole-body resistance exercise training 4x/week for 12 weeks. Either 'lower-repetition, heavier-load' or 'higher-repetition, lighter-load' intervention.

Group Type EXPERIMENTAL

Lower-repetition, heavier-load

Intervention Type BEHAVIORAL

8-12 reps/set at \~80% 1 repetition maximum

Higher-repetition, lighter-load

Intervention Type BEHAVIORAL

20-25 reps/set at \~30% 1 repetition maximum

Non-exercising control

Continue habitual physical activity for 12 weeks.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Lower-repetition, heavier-load

8-12 reps/set at \~80% 1 repetition maximum

Intervention Type BEHAVIORAL

Higher-repetition, lighter-load

20-25 reps/set at \~30% 1 repetition maximum

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Male
* Aged 18-30 years old
* Non-obese (Body mass index less than 30 kg/m2)
* Non-smoker
* Healthy based on questionnaire responses
* Resistance trained (Resistance training \> 2 times per week for 2 years, minimum 1 lower body exercise session per week)

Exclusion Criteria

* Allergies to milk proteins (whey or casein)
* Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires
* Arthritic conditions
* Individuals who consume any analgesic or anti-inflammatory drug(s), prescription or non- prescription, chronically will be excluded
* A history of neuromuscular problems
* Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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McMaster University

OTHER

Sponsor Role lead

Responsible Party

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Stuart Phillips

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Stuart M Phillips, PhD

Role: PRINCIPAL_INVESTIGATOR

McMaster University

Locations

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McMaster University

Hamilton, Ontario, Canada

Site Status

Countries

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Canada

Other Identifiers

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REB 14-333-1

Identifier Type: -

Identifier Source: org_study_id

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