Effects of Low-Intensity Blood Flow Restriction Training in Normoxia and Hypoxia Conditions

NCT ID: NCT06171841

Last Updated: 2024-06-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-11-20

Study Completion Date

2024-07-01

Brief Summary

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One approach to significantly reducing resistance training intensity while maintaining effectiveness in muscle mass and strength development involves conducting training sessions under hypoxic conditions. This is likely due to heightened physiological responses. While sports science research indicates a substantial impact of hypoxic conditions on immediate increases in metabolic stress and augmented hormonal responses, recent findings suggest that the role of their influence on skeletal muscle adaptations post-resistance training under hypoxic conditions remains unknown. Additionally, there is a lack of reports on whether the type of hypoxia applied via blood flow restriction or chamber differentiates the increase in secretion of these catecholamines in both immediate and long-term aspects.

Detailed Description

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Conditions

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Hypoxia, Altitude Blood Flow Restriction Resistance Training

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Low-Intensity Normoxia

Participants will be breathing room air, and perform low-intensity lower-body resistance exercise.

Group Type ACTIVE_COMPARATOR

low-intensity resistance training

Intervention Type OTHER

4 sets of 30/15/15/15 repetitions of leg press exercise with a load of 20-30% of one-repetition maximum (weeks 1-3: 20%, weeks 4-6: 30%) in normoxic conditions performed twice a week for 6 weeks.

High-Intensity Normoxia

Participants will be breathing room air, and perform high-intensity lower-body resistance exercise.

Group Type ACTIVE_COMPARATOR

high-intensity resistance training

Intervention Type OTHER

4 sets of 10 repetitions of leg press exercise at 70-80% one-repetition maximum (weeks 1-3: 70%, weeks 4-6: 80%) in normoxic conditions performed twice a week for 6 weeks.

Low-Intensity Normoxia with Blood Flow Restriction

Participants will be breathing room air, and perform low-intensity lower-body resistance exercise combined with blood flow restriction.

Group Type EXPERIMENTAL

low-intensity resistance training combined with blood flow restriction

Intervention Type OTHER

4 sets of 30/15/15/15 repetitions of leg press exercise with a load of 20-30% of one-repetition maximum (weeks 1-3: 20%, weeks 4-6: 30%) in normoxic conditions with lower-limbs blood flow restriction (80% total occlusion pressure) performed twice a week for 6 weeks.

Low-Intensity Hypoxia

Participants will be breathing a 13% oxygen gas mixture, and perform low-intensity lower-body resistance exercise.

Group Type EXPERIMENTAL

low-intensity resistance training in hypoxia condition

Intervention Type OTHER

4 sets of 30/15/15/15 repetitions of leg press exercise with a load of 20-30% of one-repetition maximum (weeks 1-3: 20%, weeks 4-6: 30%) in hypoxia conditions (3500 meters above sea) performed twice a week for 6 weeks.

Low-Intensity Hypoxia with Blood Flow Restriction

Participants will be breathing a 13% oxygen gas mixture, and perform low-intensity lower-body resistance exercise combined with blood flow restriction.

Group Type EXPERIMENTAL

low-intensity resistance training combined with blood flow restriction in hypoxia condition

Intervention Type OTHER

4 sets of 30/15/15/15 repetitions of leg press exercise with a load of 20-30% of one-repetition maximum (weeks 1-3: 20%, weeks 4-6: 30%) in normobaric hypoxia conditions (3500 meters above sea) with lower-limbs blood flow restriction (80% total occlusion pressure) performed twice a week for 6 weeks.

Interventions

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low-intensity resistance training

4 sets of 30/15/15/15 repetitions of leg press exercise with a load of 20-30% of one-repetition maximum (weeks 1-3: 20%, weeks 4-6: 30%) in normoxic conditions performed twice a week for 6 weeks.

Intervention Type OTHER

high-intensity resistance training

4 sets of 10 repetitions of leg press exercise at 70-80% one-repetition maximum (weeks 1-3: 70%, weeks 4-6: 80%) in normoxic conditions performed twice a week for 6 weeks.

Intervention Type OTHER

low-intensity resistance training combined with blood flow restriction

4 sets of 30/15/15/15 repetitions of leg press exercise with a load of 20-30% of one-repetition maximum (weeks 1-3: 20%, weeks 4-6: 30%) in normoxic conditions with lower-limbs blood flow restriction (80% total occlusion pressure) performed twice a week for 6 weeks.

Intervention Type OTHER

low-intensity resistance training in hypoxia condition

4 sets of 30/15/15/15 repetitions of leg press exercise with a load of 20-30% of one-repetition maximum (weeks 1-3: 20%, weeks 4-6: 30%) in hypoxia conditions (3500 meters above sea) performed twice a week for 6 weeks.

Intervention Type OTHER

low-intensity resistance training combined with blood flow restriction in hypoxia condition

4 sets of 30/15/15/15 repetitions of leg press exercise with a load of 20-30% of one-repetition maximum (weeks 1-3: 20%, weeks 4-6: 30%) in normobaric hypoxia conditions (3500 meters above sea) with lower-limbs blood flow restriction (80% total occlusion pressure) performed twice a week for 6 weeks.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Regularly physically active (at least 30 mins of structured exercise 3 times per week),
* Sea-level natives,
* Experienced in resistance training (at least one year of experience in regular resistance exercise)

Exclusion Criteria

* presence of any medical risk factors to exercise and/or exposure to altitude
* presence of any medical condition that would make the protocol unreasonably hazardous for the participant
* smokers
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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The Jerzy Kukuczka Academy of Physical Education in Katowice

OTHER

Sponsor Role lead

Responsible Party

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Michal Krzysztofik

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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The Jerzy Kukuczka Academy of Physical Education

Katowice, Silesian Voivodeship, Poland

Site Status

Countries

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Poland

Other Identifiers

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SKN/SP/569582/2023

Identifier Type: -

Identifier Source: org_study_id

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