Acute Effect of Exercise on Vascular Function

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

69 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-06-30

Study Completion Date

2019-01-23

Brief Summary

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The study objectives are the following: 1) To examine the acute vascular responses to continuous low- and moderate-intensity exercise and interval training; and 2) To examine the influence of age and gender on these responses.

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Detailed Description

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The type, intensity and duration of exercise, fitness state, and timing of measurements have been reported to influence the acute vascular responses to exercise. However, little is known regarding the influence of interval training, aging and gender on these responses. The objectives of this study are: 1) to examine the acute vascular responses to continuous low- and moderate-intensity exercise and interval training; and 2) to examine the influence of age and gender on these responses. Subjects will perform the following 3 types of treadmill exercise in a random order: 1) slow-pace walking; 2) moderate-pace walking; and 3) interval training. Flow mediated dilation using high resolution ultrasonography and arterial stiffness using applanation tonometry will be measured before, immediately after and 1-hour after each acute bout of exercise.

Conditions

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Aging

Study Design

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Observational Model Type

CASE_CROSSOVER

Study Time Perspective

PROSPECTIVE

Study Groups

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Slow-paced walking

Subjects will complete 47 minutes of walking at slow pace.

Slow-paced walking

Intervention Type OTHER

Subjects will complete 47 minutes of walking on a treadmill at a slow-pace.

Treadmill

Intervention Type DEVICE

Moderate-paced walking

Subjects will complete 47 minutes of walking at a moderate pace.

Moderate-paced walking

Intervention Type OTHER

Subjects will complete 47 minutes of walking on a treadmill at a moderate pace.

Treadmill

Intervention Type DEVICE

Interval training

Subjects will complete 40 minutes of walking alternating between a moderate and fast pace.

Interval Training

Intervention Type OTHER

Subjects will complete 40 minutes of walking on the treadmill alternating between a moderate and a fast pace.

Treadmill

Intervention Type DEVICE

Interventions

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Slow-paced walking

Subjects will complete 47 minutes of walking on a treadmill at a slow-pace.

Intervention Type OTHER

Moderate-paced walking

Subjects will complete 47 minutes of walking on a treadmill at a moderate pace.

Intervention Type OTHER

Interval Training

Subjects will complete 40 minutes of walking on the treadmill alternating between a moderate and a fast pace.

Intervention Type OTHER

Treadmill

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Men and women 18 to 79 years of age
* Women will be premenopausal or postmenopausal (either natural or surgical) defined as a cessation of menses for at least 2 years.
* Premenopausal women will be eumenorrheic.
* Able to give consent.

Exclusion Criteria

* History of hepatic disease or infection with hepatitis B, C or HIV
* History of other relevant on-going or recurrent illness
* Recent (within 3 months) or recurrent hospitalizations
* Current intake of medications that may affect study results
* Use of tobacco products
* Premenopausal women taking oral contraceptives and postmenopausal women taking hormone replacement therapy.
* Pregnancy (positive urine pregnancy test) or lactation
* Perimenopausal women

Minimum Eligible Age

18 Years

Maximum Eligible Age

79 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes