The Effect of Exercise on Myokine Production in Aging Persons

NCT ID: NCT05571709

Last Updated: 2023-03-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-09-15

Study Completion Date

2023-12-31

Brief Summary

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The incidence of age-related diseases, such as cancer and cardiovascular diseases, rapidly rises. These days, age-related diseases cause the majority of all healthcare expenses. During ageing senescent cells secrete a range of harmful inflammatory signals, which leads to chronic inflammation (inflamm-aging) and accelerates aging throughout the rest of the body. Interestingly, people who regularly exercise show less signs of inflamm-aging compared to people with a sedentary lifestyle. Molecules secreted by skeletal muscles, called myokines, may play an important role. However, the underlying molecular mechanisms remain unknown. This pilot study aims to investigate if an acute bout of resistance training is an appropriate tool to induce an increase in the release of muscle derived myokines in aged persons.

Detailed Description

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Conditions

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Aging Exercise

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Aged individuals who perform exercise training are compared to aged individuals who remain sedentary.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Aged individuals who perform exercise training

Aged individuals will perform an acute bout of resistance trainig (30 minutes). This training is focused on the lower limbs.

Group Type ACTIVE_COMPARATOR

Exercise training

Intervention Type OTHER

Resistance training of the lower limbs

Questionnaire

Intervention Type BEHAVIORAL

Physical activity questionnaire

Percutaneous muscle biopsy

Intervention Type PROCEDURE

Muscle biopsy of the vastus lateralis (m. quadriceps)

Blood sample

Intervention Type PROCEDURE

Venous blood sample

Aged individuals who stay sedentary

Aged individuals will remain seated for 30 minutes.

Group Type SHAM_COMPARATOR

Questionnaire

Intervention Type BEHAVIORAL

Physical activity questionnaire

Percutaneous muscle biopsy

Intervention Type PROCEDURE

Muscle biopsy of the vastus lateralis (m. quadriceps)

Blood sample

Intervention Type PROCEDURE

Venous blood sample

Interventions

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Exercise training

Resistance training of the lower limbs

Intervention Type OTHER

Questionnaire

Physical activity questionnaire

Intervention Type BEHAVIORAL

Percutaneous muscle biopsy

Muscle biopsy of the vastus lateralis (m. quadriceps)

Intervention Type PROCEDURE

Blood sample

Venous blood sample

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Healthy persons

Exclusion Criteria

* Smoking
* Infection \< 2 weeks ago
* Received a vaccine \< 2 weeks ago
* Allergy to Lidocain
* Immune deficiency
* Presence of a tumour or in treatment
* Usage of anti-coagulant medication
* Presence of following conditions:

* Haemophilia
* Auto-immune disease
* Cardiovascular disease
* Musculoskeletal diseases which refrains the patient from exercising
Minimum Eligible Age

65 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hasselt University

OTHER

Sponsor Role lead

Responsible Party

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Niels Hellings

Professor Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Chiel Hex, MD.

Role: PRINCIPAL_INVESTIGATOR

University of Hasselt

Locations

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Hasselt University

Diepenbeek, Limburg, Belgium

Site Status RECRUITING

Countries

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Belgium

Central Contacts

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Bert Op'T Eijnde, Prof. dr.

Role: CONTACT

+3211292121

Chiel Hex, MD.

Role: CONTACT

Facility Contacts

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Lena Fonteyn, Drs.

Role: primary

+3211269210

Leen Slaets, Dr.

Role: backup

Other Identifiers

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B1152022000006

Identifier Type: -

Identifier Source: org_study_id

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