Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
29 participants
INTERVENTIONAL
2015-06-30
2019-01-31
Brief Summary
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The investigators will test the hypothesis that a combination of normobaric hypoxia and exercise training elicits a synergistic effect on age-associated metabolic skeletal muscle dysfunction and the investigators will address the molecular mechanisms. In a randomized clinical study, the investigators will compare normoxic and hypoxic training conditions in elderly subjects. Outcome measures will focus on whole body insulin sensitivity and mitochondrial responses in skeletal muscle before and after the 8-week training intervention.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Hypoxic Exercise
Supervised, progressive aerobic exercise for 8 weeks under hypoxic conditions
Hypoxic exercise
Supervised, progressive aerobic exercise program for 8 weeks under hypoxic conditions
Normoxic exercise
Supervised, progressive aerobic exercise for 8 weeks under normoxic conditions
Normoxic Exercise
Supervised, progressive aerobic exercise program for 8 weeks under normoxic conditions
Interventions
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Hypoxic exercise
Supervised, progressive aerobic exercise program for 8 weeks under hypoxic conditions
Normoxic Exercise
Supervised, progressive aerobic exercise program for 8 weeks under normoxic conditions
Eligibility Criteria
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Inclusion Criteria
* body mass index: 20 - 35 kg/m2
* weight stable during last 6 months before screening (weight change \< 2% body weight)
* HOMA-index of insulin resistance ≥ 2 to 4 units
Exclusion Criteria
* known diagnosis of type 2 diabetes or measured HbA1c \> 6,5%
* known drug or alcohol abuse
* any contraindication to perform exercise training
* acute or chronic infections
* increased bleeding risk by history, INR \> 1,3, use of anticoagulants
55 Years
75 Years
ALL
Yes
Sponsors
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German Diabetes Center
OTHER
Hannover Medical School
OTHER
Responsible Party
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Principal Investigators
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Sven Haufe, Dr.
Role: PRINCIPAL_INVESTIGATOR
Hannover Medical School
Locations
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Hannover Medical School
Hanover, Lower Saxony, Germany
Countries
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References
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Hein M, Chobanyan-Jurgens K, Tegtbur U, Engeli S, Jordan J, Haufe S. Effect of normobaric hypoxic exercise on blood pressure in old individuals. Eur J Appl Physiol. 2021 Mar;121(3):817-825. doi: 10.1007/s00421-020-04572-6. Epub 2020 Dec 23.
Chobanyan-Jurgens K, Scheibe RJ, Potthast AB, Hein M, Smith A, Freund R, Tegtbur U, Das AM, Engeli S, Jordan J, Haufe S. Influences of Hypoxia Exercise on Whole-Body Insulin Sensitivity and Oxidative Metabolism in Older Individuals. J Clin Endocrinol Metab. 2019 Nov 1;104(11):5238-5248. doi: 10.1210/jc.2019-00411.
Other Identifiers
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HA 7037/2-1
Identifier Type: -
Identifier Source: org_study_id
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