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The Influence of High Impact Exercise on Musculoskeletal Health in Older Men

NCT ID: NCT02007460

Last Updated: 2013-12-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-01-31

Study Completion Date

2012-01-31

Brief Summary

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Osteoporotic fractures are an extremely common and serious public health issue which contribute substantially to pain, impaired mobility and morbidity in the elderly. Declines in bone strength combined with an increase risk of falls (associated with decline in muscular function with age) are the main determinants of fracture risk. Exercise that is novel and involves impact loading has the potential to improve bone strength and neuromuscular function (strength, power and balance). It is thus imperative to evaluate potential benefits of exercise in older people. The musculoskeletal responses to exercise may also be influenced by vitamin D status. It is the purpose of this study to consider the influence of a one year unilateral (one limb) high impact exercise programme on musculoskeletal health, specifically bone structure, muscle strength and power in older caucasian men. It is also the purpose of this study to determine whether this differs according to vitamin D status. The findings will reveal whether exercise can improve bone health and/or neuromuscular function, and whether improvements are dependent upon vitamin D status.

Detailed Description

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Conditions

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Bone Strength Neuromuscular Function

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Exercise leg

Group Type EXPERIMENTAL

Exercise

Intervention Type BEHAVIORAL

multidirectional unilateral hopping exercise

Control leg

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Exercise

multidirectional unilateral hopping exercise

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Healthy community dwelling men of white european origin

Exclusion Criteria

* BMI \>30 kg/m2
* History of strength training or recently ( previous 12 months) doing moderate physical activity (weight bearing, high impact)
* Recent ( previous 12 months) or current medical or surgical problems likely to affect bone metabolism or provide contraindications to high impact exercise, balance or neuromuscular function
* Any previous or existing lower back or limb problems that could be exacerbated by undertaking high impact exercise
* Any history of diagnosed or symptomatic diseases likely to influence strength, power, bone or habitual activity (including osteomalacia or impaired liver/renal function and locomotor disease, hypertension) that influences bone or muscle or precludes exercise
Minimum Eligible Age

65 Years

Maximum Eligible Age

80 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospitals Leicester NHS Trust, UK

UNKNOWN

Sponsor Role collaborator

University Hospitals of Derby and Burton NHS Foundation Trust

OTHER

Sponsor Role collaborator

Loughborough University

OTHER

Sponsor Role lead

Responsible Party

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Katherine Brooke-Wavell

Senior Lecturer in Human Biology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Katherine Brooke-Wavell, PhD

Role: PRINCIPAL_INVESTIGATOR

Loughborough University

Winston Rennie, MBBS

Role: PRINCIPAL_INVESTIGATOR

University Hospitals Leicester NHS Trust

Jonathan Folland, PhD

Role: PRINCIPAL_INVESTIGATOR

Loughborough University

Greg Summers, MD

Role: PRINCIPAL_INVESTIGATOR

Derby University Hospitals Trust

Locations

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Loughborough University

Loughborough, Leicestershire, United Kingdom

Site Status

Countries

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United Kingdom

References

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Allison SJ, Folland JP, Rennie WJ, Summers GD, Brooke-Wavell K. High impact exercise increased femoral neck bone mineral density in older men: a randomised unilateral intervention. Bone. 2013 Apr;53(2):321-8. doi: 10.1016/j.bone.2012.12.045. Epub 2013 Jan 3.

Reference Type RESULT
PMID: 23291565 (View on PubMed)

Other Identifiers

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R10-P1

Identifier Type: -

Identifier Source: org_study_id