Resistance Exercise Training at Different Intensities in Healthy and Frail Older People: A Feasibility Study

NCT ID: NCT03627793

Last Updated: 2018-10-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-08-21

Study Completion Date

2019-11-29

Brief Summary

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After the age of 40-45 years muscle mass and function progressively decline, reducing older peoples' abilities to perform tasks of daily living and also increase the risk of falls. It is known that, across the life course, resistance exercise can be of benefit in increasing muscle mass and function, yet how hard the exercise should be performed has received little attention. Current recommendations are for older people to perform exercise at 70% of the maximum they can lift, quite a high intensity that often puts older people off participating. Recent evidence in younger people has suggested that such intensities are not required.

The investigators aim to determine the feasibility of a study to investigate recruitment and adherence of older people to a study of exercise training at different intensities.

Detailed Description

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The cohort will comprise two sets of participants: frail older adults and non-frail older adults.

Each participant will receive 8 weeks of twice weekly supervised resistance training. Both the frail and non-frail participants will be randomised into either receiving high load resistance training or low load resistance training. High load resistance training will be delivered at 70% of the participants maximal capacity and low load resistance training will be delivered at 30% of maximal capacity. All resistance training will focus on the lower limb and regardless of intensity each exercise will be done to failure (unable to complete another full repetition).

Conditions

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Frail Elderly Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

RCT
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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High load non-frail

Non-frail participants who will receive resistance training at 70% of their maximal strength

Group Type ACTIVE_COMPARATOR

resistance training

Intervention Type OTHER

Moving muscles against loads with the purpose of increasing strength.

low load non-frail

Non-frail participants who will receive resistance training at 30% of their maximal strength

Group Type ACTIVE_COMPARATOR

resistance training

Intervention Type OTHER

Moving muscles against loads with the purpose of increasing strength.

high load frail

Frail participants who will receive resistance training at 70% of their maximal strength

Group Type EXPERIMENTAL

resistance training

Intervention Type OTHER

Moving muscles against loads with the purpose of increasing strength.

low load frail

Frail participants who will receive resistance training at 30% of their maximal strength

Group Type EXPERIMENTAL

resistance training

Intervention Type OTHER

Moving muscles against loads with the purpose of increasing strength.

Interventions

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resistance training

Moving muscles against loads with the purpose of increasing strength.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Non-frail - Over 65 years of age Frail - Over 65 years of age, Three or more of the following criteria: \>10lbs of weight loss unintentionally in previous year; grip strength in lowest 20% (by sex and BMI); self-reported exhaustion; walking time for 15 feet in slowest 20% (by sex and height); physical activity in the lowest 20%.

Exclusion Criteria

Non-frail - Current participation in an exercise programme. Clinical team do not think resistance exercise would be safe or unable to consent. Any other reason that precludes participation in exercise, decision made by research team in consultation with a consultant in Geriatric Medicine where required.

Frail - Current participation in an exercise programme. Clinical team do not think resistance exercise would be safe or unable to consent. Any other reason that precludes participation in exercise, decision made by research team in consultation with a consultant in Geriatric Medicine where required.
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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NHS Greater Glasgow and Clyde

OTHER

Sponsor Role collaborator

University of Glasgow

OTHER

Sponsor Role lead

Responsible Party

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Dr Evan Campbell

Research Associate

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Evan Campbell, PhD

Role: PRINCIPAL_INVESTIGATOR

Univeristy of Glasgow

Locations

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Glasgow Royal Infirmary

Glasgow, , United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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Evan Campbell, PhD

Role: CONTACT

0141 330 3076

Facility Contacts

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Evan Campbell, PhD

Role: primary

0141 330 3076

Other Identifiers

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3.0

Identifier Type: -

Identifier Source: org_study_id

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