Effects of Aging and Aerobic Exercise Training on Brain Glucose Metabolism

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

27 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-10-31

Study Completion Date

2015-02-12

Brief Summary

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Aging is associated with a loss of brain function and conditions such as dementia and Alzheimer's disease. It is likely that decreased brain metabolism is contributing to the progression of age related degenerative diseases. Aerobic exercise training can increase brain volumes and is associated with decreased risk for degenerative brain conditions. However, little is know about the changes that occur to brain metabolism with aerobic training and aging.

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Detailed Description

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Conditions

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Dementia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Exercise

Aerobic exercise

Group Type EXPERIMENTAL

High intensity aerobic training

Intervention Type BEHAVIORAL

High intensity aerobic interval training will be performed 12-weeks. Exercise training will last 1 hour per day, 5 days per week and include high intensity interval cycling at \~70-95% maximum workload for 4 minutes followed by 3 minutes of rest.

Sedentary Control

Intervention Type BEHAVIORAL

Sedentary control participants will not perform any regular exercise for 12-weeks.

Interventions

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High intensity aerobic training

High intensity aerobic interval training will be performed 12-weeks. Exercise training will last 1 hour per day, 5 days per week and include high intensity interval cycling at \~70-95% maximum workload for 4 minutes followed by 3 minutes of rest.

Intervention Type BEHAVIORAL

Sedentary Control

Sedentary control participants will not perform any regular exercise for 12-weeks.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Age 18-30 years or 65-80 years

Exclusion Criteria

* Body mass index (BMI) \>31 kg/m2
* Smoking
* Pregnancy
* Participation in structured exercise (\>2 times per week for 30 minutes or longer)
* Cardiovascular, metabolic (type 2 diabetes, fasting plasma glucose at or above 110 mg/dL and untreated hypo- or hyperthyroidism) or renal disease
* Orthopedic problems that would keep them from being able to ride an exercise bicycle, lift weights or do a combination of these exercise
* Medications that are known to impact on mitochondrial function: Corticosteroids, opiates, benzodiazepines, tricyclic antidepressants, beta blockers, sulfonylureas, insulin, anticoagulants, barbiturates, insulin sensitizers, fibrates (PPAR gamma agonist)
* Claustrophobia

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes