Aerobic Exercise Effects on Cognitive Function in Aging Individuals

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-12-25

Study Completion Date

2014-12-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Positive effects are exerted by participating in moderate exercise training with physical activity which positively affects body health, including cognitive abilities, among older adults. Thus, the investigators are trying to study the potential effects of the supervised aerobic training regimen for 12 weeks on cognitive function among older adults based on molecular changes in cellular apoptosis.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effects of the Physical Activity and Cognitive Training Program

NCT02114125

Cognitive Decline

UNKNOWN NA

The Aerobic and Cognitive Training System

NCT04120792

Healthy Aging

COMPLETED NA

Combining Exercise and Cognitive Training to Improve Everyday Function

NCT01603784

Effect of Exercise on Cognitive Function

COMPLETED PHASE3

The Effects of a Single Bout of Aerobic Exercise on Cognition: The Moderating Role of Age

NCT05226039

Cognitive Performance

COMPLETED NA

Cognitive Effects of Aerobic Exercise for MCI Adults

NCT00220467

Mild Cognitive Impairment

COMPLETED PHASE2

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Physical activity exerts many positive effects on body health, including cognitive abilities, among older adults. Nevertheless, a paucity of knowledge exists regarding the potential anti-apoptotic benefits of moderate exercise and its potential influence on cognitive function. The objective of the present study was to explore the possible connection between the anti-apoptotic mechanisms associated with exercise and cognitive performance in a cohort of 60 older adults who participated in a 12-week supervised aerobic training regimen.

A total of 120 healthy home residents and older subjects with an age range of 65 to 95 years were enrolled to participate in this study. Only, 60 subjects who met the inclusion criteria were included in this study.

The participants were categorized into two groups, specifically the control group (consisting of 30 individuals) and the exercise group (also comprising 30 individuals), based on their participation in an exercise program. Assessments of cognitive function, leisure-time physical activity (LTPA), and apoptotic-related markers such as Bcl-2, p53, and Cytochrome c were conducted both before and after a 12-week aerobic exercise intervention.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cognitive Function Exercise Training

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The participants were categorized into two groups, specifically the control group (consisting of 30 individuals) and the exercise group (also comprising 30 individuals), based on their participation in an exercise program.

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

the control group

non-exercised participants with daily life activities

Group Type NO_INTERVENTION

No interventions assigned to this group

exercise group

participants engaged in a 12-week exercise regimen structured thrice weekly.Each session's intensity was customized to match the individual's maximum and resting heart rates. The warm-up involved stretching and a 5 to 10-minute walk. In the core exercise phase, participants aimed to reach their predetermined training heart rate (THR max; between 60 to 70%) for 45-60 minutes through intervals on a treadmill, bike, or stair climber.The exercise protocol was designed to elicit physical exertion equivalent to 30-45% of their maximum oxygen consumption (VO2 max)

Group Type EXPERIMENTAL

supervised aerobic exercise

Intervention Type OTHER

In this training program, the participants exercised for 45-60 minutes through intervals on a treadmill, bike, or stair climber, three times a week for 12 weeks.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

supervised aerobic exercise

In this training program, the participants exercised for 45-60 minutes through intervals on a treadmill, bike, or stair climber, three times a week for 12 weeks.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* home resident older
* healthy individuals
* the participants were aged between 65 and 95

Exclusion Criteria

* Participants with Any physical impairments or conditions such as endocrine, immune, or psychiatric disorders
* participants with eating disorders
* participants' use of any glucocorticoid medications, which might impact the assessment of apoptotic and cognitive functions.

Minimum Eligible Age

65 Years

Maximum Eligible Age

95 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes