The Joint Effect of Air Pollution and Exercise on Cognitive Function

NCT ID: NCT04830059

Last Updated: 2025-12-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

93 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-11-01

Study Completion Date

2021-12-30

Brief Summary

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A double-blind randomized controlled trial design is used in this study. A mixed design of 2 (pollution reduction group vs. no pollution reduction group) × 3 (high intensity intermittent exercise \[HIIT\], moderate intensity of aerobic exercise \[MICT\] and control group \[CONT\]) is used. 93 subjects recruited by advertising will be randomly divided into 6 groups: high intensity exercise group (pollution reduction vs no pollution reduction), moderate intensity aerobic exercise group (pollution reduction vs no pollution reduction) and Stretching group (Control) (pollution reduction vs no pollution reduction).

Detailed Description

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Environmental intervention program In the pollution reduction groups, the air purification system is used 2 hours before the subjects entered the room to minimize the indoor PM2.5 and PM10.

Exercise intervention program including HIIT, MICT and Stretching (Control) group :

The VO2max of all subjects are measured one week before the experiment. HIIT program: 20 minutes exercise of HIIT (1min of 100% VO2max and 1min of 50% VO2max alternately) and 10 minutes of warm-up and relaxation.

MICT program: 20 minutes exercise of 70-75% VO2max and 10 minutes of warm-up and relaxation.

Stretching control group: 30 minutes of stretching, posture adjustment and rehabilitation courses taught by professional therapists.

Conditions

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Exercise Air Pollution Cognition Health Promotion

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Double blind randomized controlled trial
Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors
Participants and investigators are blinded, and part of the outcome assessors are blinded.

Study Groups

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High intensity intermittent training

HIIT exercise program: 20 minutes HIIT exercise (1min 100% VO2max and 1min 50% VO2max alternately), and warm-up and relaxation before and after exercise for 10 minutes.

Group Type EXPERIMENTAL

Exercise

Intervention Type BEHAVIORAL

Two types of exercise intervention and control group

HIIT with pollution reduction

HIIT program: 20 minutes HIIT exercise (1min 100% VO2max and 1min 50% VO2max alternately), and warm-up and relaxation before and after exercise for 10 minutes; Environmental pollution intervention program: air purification system is used order to reduce the PM2.5 and PM10.

Group Type EXPERIMENTAL

Exercise

Intervention Type BEHAVIORAL

Two types of exercise intervention and control group

Air purification

Intervention Type BEHAVIORAL

Air purification in order to reduce the PM2.5 and PM10

Moderate intensity continuous training

MICT program: 20 minutes of 70-75% VO2max exercise and 10 minutes of warm-up and relaxation before and after exercise.

Group Type EXPERIMENTAL

Exercise

Intervention Type BEHAVIORAL

Two types of exercise intervention and control group

MICT with pollution reduction

MICT program: 20 minutes of 70-75% VO2max exercise and 10 minutes of warm-up and relaxation before and after exercise; Environmental pollution intervention program: air purification system is used order to reduce the PM2.5 and PM10.

Group Type EXPERIMENTAL

Exercise

Intervention Type BEHAVIORAL

Two types of exercise intervention and control group

Air purification

Intervention Type BEHAVIORAL

Air purification in order to reduce the PM2.5 and PM10

Stretch control group

Stretching control group: 30 minutes stretching, posture adjustment and rehabilitation courses is taught by professional therapist.

Group Type EXPERIMENTAL

Exercise

Intervention Type BEHAVIORAL

Two types of exercise intervention and control group

Control with pollution reduction

Stretching control group: 30 minutes stretching, posture adjustment and rehabilitation courses is taught by professional therapist.

Environmental pollution intervention program: air purification system is used order to reduce the PM2.5 and PM10.

Group Type EXPERIMENTAL

Exercise

Intervention Type BEHAVIORAL

Two types of exercise intervention and control group

Air purification

Intervention Type BEHAVIORAL

Air purification in order to reduce the PM2.5 and PM10

Interventions

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Exercise

Two types of exercise intervention and control group

Intervention Type BEHAVIORAL

Air purification

Air purification in order to reduce the PM2.5 and PM10

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* No regular exercise in the past six months;
* Healthy people without history of disease;
* Aged between 20 and 30 years old.

Exclusion Criteria

* Professional athletes;
* Regular exercise in the past six months;
* People who are injured or have a history of disease in the past six months;
* People who have a history of taking medicine in the past six months.
Minimum Eligible Age

20 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Tsinghua University

OTHER

Sponsor Role lead

Responsible Party

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Jianxiu Liu

Research staff

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Qian Di, Sc.D.

Role: STUDY_DIRECTOR

Wanke School of public health, Tsinghua University

Xindong Ma, PhD

Role: STUDY_CHAIR

Department of physical education, Tsinghua University

Locations

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Tsinghua University

Beijing, Beijing Municipality, China

Site Status

Countries

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China

References

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Liu J, Min L, Liu R, Zhang X, Wu M, Di Q, Ma X. The effect of exercise on cerebral blood flow and executive function among young adults: a double-blinded randomized controlled trial. Sci Rep. 2023 May 22;13(1):8269. doi: 10.1038/s41598-023-33063-9.

Reference Type DERIVED
PMID: 37217511 (View on PubMed)

Liu J, Zhang Y, Li X, Wang D, Shi B, You Y, Min L, Luo B, Li Y, Di Q, Ma X. Exercise improves mental health status of young adults via attenuating inflammation factors but modalities matter. Front Psychiatry. 2022 Dec 14;13:1067890. doi: 10.3389/fpsyt.2022.1067890. eCollection 2022.

Reference Type DERIVED
PMID: 36590621 (View on PubMed)

Other Identifiers

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THU2021

Identifier Type: -

Identifier Source: org_study_id

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