Synergistic Effects of Aerobic Exercise and Cognitive Training on Cognition in Stroke Patients With Cognitive Decline
NCT ID: NCT02550990
Last Updated: 2016-12-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
75 participants
INTERVENTIONAL
2015-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Cognitive training group
One 60-min session of cognitive training. Before and after the treatment, a total of 2 evaluations were conducted, including clinical assessments and blood test (each 18c.c.). A saliva sample (2 mL) will only be collected once from each subject. A follow-up assessment of clinical outcomes will be conducted at six month after the end of the course of treatment.
Cognitive training
Aerobic exercise training group
One 60-min session of aerobic exercise training. Before and after the treatment, a total of 2 evaluations were conducted, including clinical assessments and blood test (each 18c.c.). A saliva sample (2 mL) will only be collected once from each subject. A follow-up assessment of clinical outcomes will be conducted at six month after the end of the course of treatment.
Aerobic exercise training
Sequential training group
One 30-min session of aerobic exercise training + one 30-min session of cognitive training.
Before and after the treatment, a total of 2 evaluations were conducted, including clinical assessments and blood test (each 18c.c.). A saliva sample (2 mL) will only be collected once from each subject. A follow-up assessment of clinical outcomes will be conducted at six month after the end of the course of treatment.
Sequential combination of aerobic exercise and cognitive training
Interventions
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Cognitive training
Aerobic exercise training
Sequential combination of aerobic exercise and cognitive training
Eligibility Criteria
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Inclusion Criteria
2. Age range from 20 to 90 years
3. MMSE score ≥ 19
4. MoCA\<26
5. Self- or informant-reported memory or cognitive complaints or CDR scale ≤ 0.5
6. Able to follow the study instruction
7. Adequate cardiopulmonary function to perform aerobic exercise
8. Able to walk with or without assistive devices
Exclusion Criteria
2. Concomitant with other neurological disorders (e.g., Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis)
3. Current participation in another interventional trial
20 Years
90 Years
ALL
No
Sponsors
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Chang Gung Memorial Hospital
OTHER
Responsible Party
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Locations
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Chang Gung Memorial Hospital
Kwei-Shan, Taoyuan, Taiwan
Chiayi Chang Gung Memorial Hospital
Chiayi City, , Taiwan
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, , Taiwan
Keeling Chang Gung Memorial Hospital
Keelung, , Taiwan
Taipei Chang Gung Memorial Hospital
Taipei, , Taiwan
Taoyuan Chang Gung Memorial Hospital
Taoyuan, , Taiwan
Countries
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Central Contacts
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Facility Contacts
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Ching-Yi Wu, ScD
Role: primary
Shi-Zhe Lin, MS
Role: primary
Ku-Chou Chang, MD
Role: primary
Chia-Ling Chen, PhD
Role: primary
Chia-Ling Chen, PhD
Role: primary
Chia-Ling Chen, PhD
Role: primary
References
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Gibson E, Koh CL, Eames S, Bennett S, Scott AM, Hoffmann TC. Occupational therapy for cognitive impairment in stroke patients. Cochrane Database Syst Rev. 2022 Mar 29;3(3):CD006430. doi: 10.1002/14651858.CD006430.pub3.
Yeh TT, Wu CY, Hsieh YW, Chang KC, Lee LC, Hung JW, Lin KC, Teng CH, Liao YH. Synergistic effects of aerobic exercise and cognitive training on cognition, physiological markers, daily function, and quality of life in stroke survivors with cognitive decline: study protocol for a randomized controlled trial. Trials. 2017 Aug 31;18(1):405. doi: 10.1186/s13063-017-2153-7.
Other Identifiers
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104-4892A3
Identifier Type: -
Identifier Source: org_study_id