Enhancing Function in Later Life: Exercise and Functional Network Connectivity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

317 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-04-30

Study Completion Date

2018-12-03

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Physiological and neurocognitive changes experienced as a result of increasing age may influence socioemotional functioning and economic behaviors, yet, the mechanisms through which these changes occur are not well understood. Studies have also shown that aerobic exercise may protect against age-related cognitive decline in other domains. This research is designed to test the hypothesis that aerobic exercise will enhance social, emotional and economic functioning in older adults, and that these effects will occur via the effect of exercise on neurocognitive structure and function assessed via magnetic resonance imaging (MRI). Advancing our knowledge of the mechanisms that influence emotional, social and economic functioning could inform the development of targeted treatments and prevention programs for older adults.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Aerobic Exercise Effects on Cognitive Function in Aging Individuals

NCT06650345

Cognitive Function Exercise Training

COMPLETED NA

Aerobic Exercise for Older Adults at Increased Risk of Alzheimer's Disease and Related Dementias

NCT03035851

Alzheimer Disease Dementia

UNKNOWN NA

Aerobic Exercise and Cognitive Training in Older Adults

NCT02787655

Sedentary Lifestyle

COMPLETED NA

Aerobic Exercise to Improve Executive Language Function In Older Adults

NCT00979069

Aging

COMPLETED NA

Effects of the Physical Activity and Cognitive Training Program

NCT02114125

Cognitive Decline

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Aging

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

MICT + IT

Moderate Intensity Continuous Training+Interval Training

Group Type EXPERIMENTAL

Moderate Intensity Continuous Training+Interval Training

Intervention Type BEHAVIORAL

LICT

Low Intensity Continuous Training

Group Type ACTIVE_COMPARATOR

Low Intensity Continuous Training

Intervention Type BEHAVIORAL

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Moderate Intensity Continuous Training+Interval Training

Intervention Type BEHAVIORAL

Low Intensity Continuous Training

Intervention Type BEHAVIORAL

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

MICT+IT LICT

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age 25-35 for younger adults, and age 60 or over for older adults
* Sedentary (i.e., \< 60 minutes per week of moderate physical activity in the past 6-months)
* Able to make fewer than 3 errors on the Pfeiffer Mental Status192
* Willing to accept random assignment to condition (older adults)
* Physically capable of safely engaging in moderate exercise activity (i.e., no injuries, physical impairments, or pre-existing contraindications) as assessed by a study physician
* Able to successfully complete a maximal exercise test without evidence of cardiac or other abnormalities
* Planning to remain in the Boulder-Denver metro area for the next 4 months (older adults)

Exclusion Criteria

* Are a heavy smoker (\>20 pack years)
* Are diabetic
* Have a body size exceeding the capacity of the magnetic resonance imaging machine (approximately 23" in diameter)
* Are on antipsychotic medications
* Are currently under treatment for any psychiatric disorder, including clinical depression, Alzheimer's, or dementia
* Are currently pregnant
* Have magnetic resonance imaging contraindications (i.e., non-removable metallic implants, claustrophobia, traumatic brain injury, current pregnancy, etc.)

Minimum Eligible Age

25 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes