Skeletal Muscle and Adipose Tissue Responses After Acute Exercise: Comparing Effects of Three Different Intensities

NCT ID: NCT05365334

Last Updated: 2024-07-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-12-13

Study Completion Date

2023-06-23

Brief Summary

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The study will assess the exercise-induced changes in chromatin accessibility and gene expression in a cell type-specific manner in skeletal muscle from healthy adults in response to exercise at three different intensities - 1) low-intensity continuous exercise, 2) moderate-intensity continuous exercise, and 3) high-intensity interval exercise.

Detailed Description

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Conditions

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Cellular Responses Within Skeletal Muscle in Response to Exercise of Different Intensities Relationship Between the Cellular Responses in Skeletal Muscle and the Changes in the Metabolomic Profile Changes Within Adipose Tissue in Response to Exercise at the Three Different Intensities

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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low-intensity continuous exercise

subjects will exercise at 30% maximal oxygen consumption (VO2max) for 45-60 minutes

Group Type EXPERIMENTAL

Low intensity exercise session

Intervention Type BEHAVIORAL

subjects will exercise at 30% maximal oxygen consumption (VO2max) for 45-60 minutes

moderate-intensity continuous exercise

subjects will exercise at 65% maximal oxygen consumption (VO2max) for 30-45 minutes

Group Type EXPERIMENTAL

Moderate intensity exercise session

Intervention Type BEHAVIORAL

subjects will exercise at 65% maximal oxygen consumption (VO2max) for 30-45 minutes

high-intensity interval exercise

subjects will completed 10x1minute exercise intervals at maximal oxygen consumption (VO2max) with 1 minute active recovery between

Group Type EXPERIMENTAL

High intensity exercise session

Intervention Type BEHAVIORAL

subjects will completed 10x1minute exercise intervals at maximal oxygen consumption (VO2max) with 1 minute active recovery between

Interventions

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Low intensity exercise session

subjects will exercise at 30% maximal oxygen consumption (VO2max) for 45-60 minutes

Intervention Type BEHAVIORAL

Moderate intensity exercise session

subjects will exercise at 65% maximal oxygen consumption (VO2max) for 30-45 minutes

Intervention Type BEHAVIORAL

High intensity exercise session

subjects will completed 10x1minute exercise intervals at maximal oxygen consumption (VO2max) with 1 minute active recovery between

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Age:18-40
* Body Mass Index: 20-30 kg/m2
* Must engage in regularly planned aerobic-type exercise at moderate-vigorous intensity, 3 times per week for at least 30-60 minutes/session
* Women must have regularly occurring menses and must be premenopausal
* Subject willingness to opt-in for the Michigan Genomics Initiative (MGI) Repository

Exclusion Criteria

* Evidence/history of cardiovascular or metabolic disease.
* Taking anti-coagulate medications or medications known to affect metabolism or inflammation
* Weight instability ≥ ±3kg in the last 6 months
* Tobacco or e-cigarette users
* Women must not be pregnant or actively lactating
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Michigan

OTHER

Sponsor Role lead

Responsible Party

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Jeffrey F Horowitz

Professor of Movement Science and Director of the Substrate Metabolism Laboratory (SML) at the University of Michigan School of Kinesiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of Michigan

Ann Arbor, Michigan, United States

Site Status

Countries

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United States

Other Identifiers

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HUM00204857

Identifier Type: -

Identifier Source: org_study_id

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