Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
NA
35 participants
INTERVENTIONAL
2018-12-18
2020-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
SUPPORTIVE_CARE
NONE
Study Groups
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resistance training exercise
All participants complete one session of resistance training exercise
Resistance training exercise
randomized complete crossover for acute resistance training exercise session
aerobic training exercise
All participants complete one session of aerobic training exercise
Aerobic training exercise
randomized complete crossover for acute aerobic exercise training exercise session
Interventions
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Resistance training exercise
randomized complete crossover for acute resistance training exercise session
Aerobic training exercise
randomized complete crossover for acute aerobic exercise training exercise session
Eligibility Criteria
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Inclusion Criteria
* "Older" Adults: ages 55-75 and if a female postmenopausal
* Participants classified as "trained" must participate in at least 30 minutes of moderate to vigorous intensity cardiovascular activity at least 3 days per week and engage in resistance training for all of the major muscle groups approximately 2 days / week. They must have upheld this activity for the past 3 months
* Participants classified as "untrained" must be participating in less than 30 minutes of moderate to vigorous intensity cardiovascular activity and less than 2 days of resistance training per week for at least the last 3 months.
Exclusion Criteria
* Range of motion restrictions that would prevent them from participating in aerobic or resistance training with proper form (they must be ambulatory)
* aking medications (prescription or over the counter) known to influence immune function, including daily NSAID's, beta blockers, statins, bisphosphonates, or steroids.
* Have known cardiovascular, respiratory, metabolic, or renal disease, with the exception of controlled hypertension (as defined by resting BP below 140/90) and/or controlled asthma (self-reported).
* Be pregnant
* Be unable to complete all visits (i.e. must not be planning to leave the Houston area long-term before concluding their participation in the study which will span several weeks)
* Fall outside of a BMI range of (18.5 - 30)
* Consume alcohol or recreational drugs for 24h prior to visits
* Older women cannot be pre-menopausal (must have not had a menses for at least 12 months)
* Unable to speak or read English
* Participants must not have scheduling conflicts that would prevent them from reporting to the laboratory of integrated physiology 4 times over the course of the study
18 Years
75 Years
ALL
Yes
Sponsors
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University of Houston
OTHER
Responsible Party
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Melissa M Markofski
Assistant Professor
Principal Investigators
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Melissa Markofski, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Houston
Locations
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University of Houston
Houston, Texas, United States
Countries
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References
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Graff RM, Jennings K, LaVoy ECP, Warren VE, Macdonald BW, Park Y, Markofski MM. T-cell counts in response to acute cardiorespiratory or resistance exercise in physically active or physically inactive older adults: a randomized crossover study. J Appl Physiol (1985). 2022 Jul 1;133(1):119-129. doi: 10.1152/japplphysiol.00301.2021. Epub 2022 May 26.
Other Identifiers
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STUDY00001191
Identifier Type: -
Identifier Source: org_study_id
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