Comparing Acute Aerobic and Resistance Exercise

NCT ID: NCT03794050

Last Updated: 2023-03-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

35 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-12-18

Study Completion Date

2020-03-31

Brief Summary

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The purpose of this study is to determine the effect of age and fitness level on the physiological response to an acute bout of resistance or aerobic exercise.

Detailed Description

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Young and middle-aged to older adults who are physically active or not physically active will participate in two moderate to vigorous intensity exercise bouts: aerobic exercise and resistance training exercise. Blood will be collected to assess immune function and metabolism.

Conditions

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Exercise Physiology

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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resistance training exercise

All participants complete one session of resistance training exercise

Group Type EXPERIMENTAL

Resistance training exercise

Intervention Type OTHER

randomized complete crossover for acute resistance training exercise session

aerobic training exercise

All participants complete one session of aerobic training exercise

Group Type EXPERIMENTAL

Aerobic training exercise

Intervention Type OTHER

randomized complete crossover for acute aerobic exercise training exercise session

Interventions

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Resistance training exercise

randomized complete crossover for acute resistance training exercise session

Intervention Type OTHER

Aerobic training exercise

randomized complete crossover for acute aerobic exercise training exercise session

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* "Young" Adults: ages 18-30
* "Older" Adults: ages 55-75 and if a female postmenopausal
* Participants classified as "trained" must participate in at least 30 minutes of moderate to vigorous intensity cardiovascular activity at least 3 days per week and engage in resistance training for all of the major muscle groups approximately 2 days / week. They must have upheld this activity for the past 3 months
* Participants classified as "untrained" must be participating in less than 30 minutes of moderate to vigorous intensity cardiovascular activity and less than 2 days of resistance training per week for at least the last 3 months.

Exclusion Criteria

* Have any contraindications to moderate to vigorous exercise
* Range of motion restrictions that would prevent them from participating in aerobic or resistance training with proper form (they must be ambulatory)
* aking medications (prescription or over the counter) known to influence immune function, including daily NSAID's, beta blockers, statins, bisphosphonates, or steroids.
* Have known cardiovascular, respiratory, metabolic, or renal disease, with the exception of controlled hypertension (as defined by resting BP below 140/90) and/or controlled asthma (self-reported).
* Be pregnant
* Be unable to complete all visits (i.e. must not be planning to leave the Houston area long-term before concluding their participation in the study which will span several weeks)
* Fall outside of a BMI range of (18.5 - 30)
* Consume alcohol or recreational drugs for 24h prior to visits
* Older women cannot be pre-menopausal (must have not had a menses for at least 12 months)
* Unable to speak or read English
* Participants must not have scheduling conflicts that would prevent them from reporting to the laboratory of integrated physiology 4 times over the course of the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Houston

OTHER

Sponsor Role lead

Responsible Party

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Melissa M Markofski

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Melissa Markofski, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Houston

Locations

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University of Houston

Houston, Texas, United States

Site Status

Countries

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United States

References

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Graff RM, Jennings K, LaVoy ECP, Warren VE, Macdonald BW, Park Y, Markofski MM. T-cell counts in response to acute cardiorespiratory or resistance exercise in physically active or physically inactive older adults: a randomized crossover study. J Appl Physiol (1985). 2022 Jul 1;133(1):119-129. doi: 10.1152/japplphysiol.00301.2021. Epub 2022 May 26.

Reference Type DERIVED
PMID: 35616304 (View on PubMed)

Other Identifiers

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STUDY00001191

Identifier Type: -

Identifier Source: org_study_id

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