Effects of a Warm-up on Immune Response to Exercise

NCT ID: NCT04868136

Last Updated: 2022-05-17

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 24 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-07-15
• Study Completion Date: 2021-09-30

Brief Summary

This randomized cross-over study compares two identical cardiorespiratory exercise bouts, differing only in the inclusion or exclusion of a dynamic period of increasing exercise intensity prior to the exercise bout. Planned comparisons include physiological responses and perceived effort during exercise, leukocyte mobilization, and mood between the two exercise sessions.

Detailed Description

Physically active adult men and women are asked to complete three study visits to the laboratory. On Visit 1, participants provide informed consent and are screened for study inclusion criteria: being between 18 and 40 years of age, a non-smoker, not pregnant, free of disease impacting exercise performance or immunity, and performing at least one hour per week of vigorous exercise training (any modality) for at least the prior six months. Participants also complete an incremental submaximal exercise test on a stationary bicycle. The results of this test are used to calculate the resistance corresponding to 80% of estimated maximal heart rate. Participants return within 2-14 days for Visits 2 and 3. These visits consist of 30 min of bicycling at this resistance. One visit included a 10 min dynamic warm-up prior to the exercise bout. Participants were stratified by sex and randomized such that half of the men and women completed the exercise trial with warm-up during Visit 2.

Heart rate, perceived exertion, and wattage are recorded during each minute of the exercise bouts. Participants donate blood before, immediately after, and 1h after each exercise. Blood is analyzed by flow cytometry to characterize leukocyte subsets. After each exercise session, participants complete surveys assessing mood and affect.

Physiological, immunological, and psychological parameters recorded will be compared within participants between the two experimental exercise sessions using appropriate statistical tests. p<0.05 will be accepted as significant.

Conditions

Physiological and Psychological Responses to Exercise

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Warm-up, then no warm-up

Participants' visit 2 included 10 minutes of gradually increasing intensity prior to the 30 minute exercise session. Participants' visit 3 consisted of the 30 minute exercise session without a warm-up.

Group Type: EXPERIMENTAL

Exercise

Intervention Type: BEHAVIORAL

30 minutes of exercise at 80% of maximum predicted heart rate performed on an indoor stationary bicycle. Exercise was preceded by 10 min of gradually increasing cycling intensity in one of two exercise trials

No warm-up, then warm-up

Participants' visit 2 consisted of the 30 minute exercise session without a warm-up. Participants' visit 3 included 10 minutes of gradually increasing intensity prior to the 30 minute exercise session.

Group Type: EXPERIMENTAL

Exercise

Intervention Type: BEHAVIORAL

30 minutes of exercise at 80% of maximum predicted heart rate performed on an indoor stationary bicycle. Exercise was preceded by 10 min of gradually increasing cycling intensity in one of two exercise trials

Interventions

Exercise

30 minutes of exercise at 80% of maximum predicted heart rate performed on an indoor stationary bicycle. Exercise was preceded by 10 min of gradually increasing cycling intensity in one of two exercise trials

Intervention Type: BEHAVIORAL

Other Intervention Names

Cardiorespiratory exercise

Eligibility Criteria

Inclusion Criteria

• identifies as exercising 1-3 hours per week or more than 6 hours per week, on average (last 6 months)
• meets American College of Sports Medicine criteria for participation in exercise

Exclusion Criteria

• underlying medical problems that contraindicate supervised high intensity exercise
• past or present history of autoimmune disease, HIV, hepatitis, stroke, or cardiovascular disease
• chronic/debilitating arthritis
• central or peripheral nervous disorders
• asthma, emphysema, or bronchitis
• bedridden in the past three months
• history of blood clotting disorders
• administration of any medication that might affect physiological response to exercise
• functional or cognitive impairment that would limit exercise performance or prohibit informed consent
• having any common-cold or influenza like symptoms (scratchy throat, runny nose, inflamed sinuses, frequent sneezing or coughing) in the last 2 weeks
• pregnancy
• tobacco use

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Houston

OTHER

Sponsor Role: lead

Responsible Party

Emily C Lavoy

Assistant Profesor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Emily C LaVoy, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Houston

Locations

University of Houston

Houston, Texas, United States

Countries

United States

Other Identifiers

STUDY00000990

Identifier Type: -

Identifier Source: org_study_id