Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
102 participants
INTERVENTIONAL
2024-03-01
2025-04-03
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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Acute effects: Moderate Intensity Exercise
Participants with a moderate fitness level (determined by VO2max value recorded during graded exercise test) will cycle 30minutes exercise below ventilatory threshold. Outcome measures will be compared within-subject across blood sampled before exercise, immediately after exercise, and 2h post exercise. The order of the exercise sessions (above vs below threshold) will be randomized.
Acute exercise-moderate intensity
30 minutes of cycling exercise at moderate (90% of first ventilatory threshold)
Acute effects: Heavy intensity exercise
Participants with a moderate fitness level (determined by VO2max value recorded during graded exercise test) will bicycle 30 minutes above ventilatory threshold. Outcome measures will be compared within-subject across blood sampled before exercise, immediately after exercise, and 2h post exercise. The order of the exercise sessions (above vs below threshold) will be randomized.
Acute effects-heavy intensity
Participants will cycle 30 minutes at heavy (110% of first ventilatory threshold) intensity
Interventions
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Acute exercise-moderate intensity
30 minutes of cycling exercise at moderate (90% of first ventilatory threshold)
Acute effects-heavy intensity
Participants will cycle 30 minutes at heavy (110% of first ventilatory threshold) intensity
Eligibility Criteria
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Inclusion Criteria
* individuals presenting with average (40th-60th percentile) cardiorespiratory fitness (i.e., VO2max/VO2peak) for their age and sex will be included in acute exercise experiments; individuals with VO2max/VO2peak value \>20ml/kg/min will be included in cardiorespiratory fitness experiments
* individuals categorized as 'low risk' for a cardiovascular event/heart disease when screened by American College of Sports Medicine (ACSM) criteria
Exclusion Criteria
* Individuals with contraindications to exercise testing will be excluded
* Individuals with musculoskeletal impairments preventing them from exercising on a cycle ergometer
* Individuals with disease history known to impact the immune system and/or systemic metabolism will be excluded, including autoimmune diseases, HIV, Hepatitis, diabetes, cancer (completed treatment within \<6 months prior), hyper- or hypothyroidism
* Pregnancy
* Individuals using medications known to impact the cardiopulmonary and/or immune response to exercise with be excluded, including those using medication to control blood pressure (e.g., beta-blockers), daily steroidal and nonsteroidal anti-inflammatories (except daily aspirin), prescription allergy medication, ADHD medication (Ritalin or Adderall), thyroid medication (e.g., Levothyroxine), and chemotherapy (including treatments within the last 6 months).
* Individuals habitually using tobacco products within the last 6 months or with excessive alcohol intake (\>10 drinks/week)
20 Years
40 Years
ALL
Yes
Sponsors
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University of Houston
OTHER
Responsible Party
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Emily C Lavoy
Associate Professor
Locations
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University of Houston
Houston, Texas, United States
Countries
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Other Identifiers
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STUDY00004272
Identifier Type: -
Identifier Source: org_study_id
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