Effect of Exercise on Elevated C-reactive Protein Concentrations in Formerly Inactive Adults

NCT ID: NCT00113061

Last Updated: 2016-07-29

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 162 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2004-07-31
• Study Completion Date: 2006-06-30

Brief Summary

The purpose of this study is to determine the effect of exercise training on elevated C-reactive protein (CRP) concentrations, an indicator of inflammation, in initially inactive women and men.

Detailed Description

BACKGROUND:

CRP, a marker of systemic inflammation, has been reported to be an independent predictor of cardiovascular disease in both women and men. Recently published data from cross-sectional analyses showed that CRP is inversely related to cardiorespiratory fitness, and that this association is independent of body mass index. Regular exercise may affect CRP levels, and can possibly be used as a means of reducing elevated CRP levels. Though there are a number of studies focusing on related topics, there are no published reports from randomized clinical trials on the effect of exercise training alone on CRP levels.

DESIGN NARRATIVE:

An estimated 200 individuals will be randomly assigned to either a no exercise control group or an exercise group. Exercising individuals will participate in 3 or 4 training sessions each week for 4 months, and will progress to a total energy expenditure of 16 kcal [kg(-1), week(-1)], which is an exercise dose at the upper end of current public health recommendations for physical activity. The target exercise intensity will be 50-70% of baseline volume of oxygen consumed (V02 max). VO2 max is the maximal rate of oxygen consumption during exercise, and is a measurement of fitness. The primary outcome measure will be plasma CRP concentration. Secondary outcomes will be changes in variables that are potential mechanisms through which regular exercise might reduce CRP. These variables include visceral adiposity, the cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), and heart rate variability as a measure of autonomic balance. Although the primary outcome is CRP level, this study will also contribute significantly to the limited body of literature examining the effect of exercise on the variables of visceral adiposity, cytokines, and heart rate variability.

Conditions

Cardiovascular Diseases; Heart Diseases; Obesity

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION

Interventions

Exercise

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Physically inactive
• C-reactive protein level at least 2.0 mg/L but less than 10.0 mg/L upon study entry
• Body mass index between 18.5 kg/square meter and 40.0 kg/square meter as measured at study entry
• Does not smoke
• Total cholesterol at least 240 mg/dl with LDL-C at least 160 mg/dl OR LDL less than 190 mg/dl and Framingham less than 10%
• Triglyceride levels no higher than 300 mg/dl
• Fasting glucose level less than 126
• Systolic blood pressure less than 140 mm Hg and/or diastolic blood pressure less than 90 mm Hg as measured at study entry
• If taking an oral contraceptive, aspirin, ibuprofen, or other anti-inflammatory medications, must be on a stable dose for 6 months prior to study entry
• If taking a cholesterol medication, including statins, blood pressure medication (including ace inhibitors), or multi-vitamins, must be on a stable dose for 2 months prior to study entry

Exclusion Criteria

• Using a beta blocker, hormone replacement therapy, or corticosteroids (except inhalers)
• Any rheumatologic, orthopedic, neurological, or autoimmune diseases, or seizure disorder
• Any significant cardiovascular disease or disorders including, but not limited to, stent or coronary artery bypass grafting
• Cardiac dysrhythmias including, but not limited to, left bundle branch block, atrial fibrillation, pacemaker, or automatic implantable cardioverter defibrillator
• Any surgery, broken bones, blood donation, or anaphylactic shock within 6 months of study entry
• Any sprain or strain, removal of wisdom teeth, or use of antibiotics within 3 months of study entry
• History of stroke or TIA
• History of cancer within at least 5 years of study entry
• Diabetes or glucose intolerance
• Planning on participating in any other research trials during the next year
• Currently pregnant
• Planning to becoming pregnant during the next year

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role: lead

Principal Investigators

Timothy S. Church

Role: PRINCIPAL_INVESTIGATOR

Pennington Biomedical Research Center

Locations

Pennington Biomedical Research Center, LSU System

Baton Rouge, Louisiana, United States

Countries

United States

References

Church TS, Earnest CP, Thompson AM, Priest EL, Rodarte RQ, Saunders T, Ross R, Blair SN. Exercise without weight loss does not reduce C-reactive protein: the INFLAME study. Med Sci Sports Exerc. 2010 Apr;42(4):708-16. doi: 10.1249/MSS.0b013e3181c03a43.

Reference Type: DERIVED

PMID: 19952828 (View on PubMed)

Other Identifiers

R01HL075442

Identifier Type: NIH

Identifier Source: secondary_id

View Link

180

Identifier Type: -

Identifier Source: org_study_id