Acute Responses to Exercise in Females and Males With Symptomatic Atrial Fibrillation
NCT ID: NCT05085860
Last Updated: 2025-11-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
36 participants
INTERVENTIONAL
2022-02-08
2026-04-01
Brief Summary
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Detailed Description
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The main purpose of this pilot project is to measure the feasibility of conducting a randomized crossover study examining short-term changes in AF symptoms in symptomatic females and males with paroxysmal or persistent AF when they engage in a standard week of exercise (i.e. moderate-intensity continuous training \[MICT\] or high-intensity interval training \[HIIT\]) compared to a control week (i.e. no moderate to vigorous exercise over 7 days). As secondary outcomes we will explore sex differences in short-term changes in AF symptoms (self reported with a questionnaire) and AF status (device measured with a wireless four-finger AliveCor KardiaMobile ECG) when symptomatic patients with AF engage in a standard week of exercise (i.e. HIIT, MICT) compared to a control week. Results from this pilot study will provide novel insight into the typical acute response to exercise in females and males with AF, and will inform appropriate approaches for the conduct of a future larger trial. This work is key to informing practitioners and patients of the typical acute exercise response in the AF population with the goal of facilitating exercise prescription and participation.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
NONE
Study Groups
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Moderate Intensity Continuous Training (MICT)
Participants will do 3 sessions of moderate-intensity continous exercise training over 7 days
Moderate-intensity continuous training (MICT)
Participants will engage in exercise and record AF symptoms prospectively over 7 days
High Intensity Interval Training (HIIT)
Participants will do 3 sessions of high-intensity interval training over 7 days
High-intensity interval training (HIIT)
Participants will engage in exercise and record AF symptoms prospectively over 7 days
Rest
Participants will abstain from doing moderate- to high-intensity interval training over 7 days
No interventions assigned to this group
Interventions
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Moderate-intensity continuous training (MICT)
Participants will engage in exercise and record AF symptoms prospectively over 7 days
High-intensity interval training (HIIT)
Participants will engage in exercise and record AF symptoms prospectively over 7 days
Eligibility Criteria
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Inclusion Criteria
* Rate controlled (resting ventricular rate \<110 bpm)
* Able to do a symptom limited exercise test
* At least 40 years of age
* Self-reports being symptomatic in the past 4 weeks
* If female, self-reports being post-menopausal
* Able to read and understand English or French
* Agrees to sign informed consent
Exclusion Criteria
* Unstable angina or uncontrolled diabetes mellitus; or established diagnosis of severe mitral or aortic stenosis, or hypertrophic obstructive cardiomyopathy with significant obstruction
* Unable to access the Internet or a phone (iPhone and iPad require iOS version 10.0 and up, Android requires version 6.0 and up) during the study period
* Has an automated external defibrillator, an implantable cardioverter defibrillator or other types of pacemaker
* Unwilling or unable to complete the three conditions
* Unable to provide written, informed consent
40 Years
ALL
No
Sponsors
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Ottawa Heart Institute Research Corporation
OTHER
Responsible Party
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Principal Investigators
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Jennifer Reed, PhD
Role: PRINCIPAL_INVESTIGATOR
Ottawa Heart Institute Research Corporation
Locations
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University of Ottawa Heart Institute
Ottawa, Ontario, Canada
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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20210524-01H
Identifier Type: -
Identifier Source: org_study_id
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