Anti-inflammatory Effect of Aerobic Exercise in Individual With Increased Cardiovascular Risk

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

68 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-12-31

Study Completion Date

2008-04-30

Brief Summary

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Aerobic physical activity attenuates systemic inflammatory activity in individuals with cardiovascular risk.

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Detailed Description

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Background: Observational studies suggest that exercise has anti-inflammatory effect, however this idea has not been definitively confirmed by randomized clinical trials.

Objective: To test the hypothesis that aerobic exercise attenuates systemic inflammatory activity in individuals with cardiovascular risk.

Methods: Randomized controlled trial, which included 68 sedentary individuals, with at least two risk factors for coronary heart disease or established cardiovascular disease. The volunteers were randomized to 3 months of supervised aerobic training or just advice when healthy lifestyles. C-reactive protein (CRP) was measured by the method of high sensitivity before and after 3 months of intervention.

Conditions

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Inflammation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Training

Aerobic

Group Type EXPERIMENTAL

Aerobic Exercise

Intervention Type BEHAVIORAL

Control

Not exercise

Group Type PLACEBO_COMPARATOR

Only Counseling

Intervention Type BEHAVIORAL

Interventions

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Aerobic Exercise

Intervention Type BEHAVIORAL

Only Counseling

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

\- Individuals with are between 40 to 70 years, no regular exercise, and at least two risk factor for cardiovascular disease (diabetes, hypertension, dyslipidemia, smoking) or documented cardiovascular disease.