Effect of Aerobic Training on Asthmatic Patients

NCT ID: NCT00989365

Last Updated: 2009-10-05

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 100 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2007-01-31
• Study Completion Date: 2009-09-30

Brief Summary

The investigators hypothesize that aerobic training can reduce anxiety, depression and airway inflammation and those benefits may be related to changes in autonomic system.

Detailed Description

One-hundred patients with moderate or severe persistent asthma, age ranging from 20 to 50 years-old recruited after a medical consultation. Asthma diagnosis based on GINA1 and patients were under medical treatment for at least 6-months and considered clinically stable (no crises and changes in medication for at least 30 days). Patients diagnosed with cardiovascular, pulmonary or musculoskeletal diseases impairing exercise training were excluded.

Experimental Design: Patients were studied between 2 medical consultation to avoid changes in medication during the study and patients were randomized (by drawing lots) into either Control or Training groups. CG was submitted to a 4-hour educational program and a breathing exercise program and TG was submitted to the same CG procedures plus an aerobic training program individually based on VO2max. Before and after the intervention, patients performed pulmonary function test and cardiopulmonary exercise testing and as well as fulfilled questionnaires to quantify asthma specific HRQL and anxiety and depression levels. Asthma daily symptoms were evaluated monthly.

Conditions

Anxiety; Depression; Airway Inflammation

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Patient cousenling

Improve medicine use Self control asthma crisis Ambient hygiene

Group Type: OTHER

Aerobic training

Intervention Type: OTHER

Treadmill training

Interventions

Aerobic training

Treadmill training

Intervention Type: OTHER

Other Intervention Names

Exercise conditioning

Eligibility Criteria

Inclusion Criteria

• 20-50 years old
• moderate and severe asthma

Exclusion Criteria

• other pulmonary or cardiovascular disease

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Fundação de Amparo à Pesquisa do Estado de São Paulo

OTHER_GOV

Sponsor Role: collaborator

Conselho Nacional de Desenvolvimento Científico e Tecnológico

OTHER_GOV

Sponsor Role: collaborator

Laboratório de Investigação Médica

UNKNOWN

Sponsor Role: collaborator

University of Sao Paulo General Hospital

OTHER

Sponsor Role: lead

Responsible Party

School of Medicine, University of São Paulo

Principal Investigators

Celso RF Carvalho, PhD

Role: STUDY_CHAIR

School of Medicine, University of São Paulo

Locations

Clinical Hospital, School of Medicine, University of São Paulo

São Paulo, São Paulo, Brazil

Countries

Brazil

References

Fanelli A, Cabral AL, Neder JA, Martins MA, Carvalho CR. Exercise training on disease control and quality of life in asthmatic children. Med Sci Sports Exerc. 2007 Sep;39(9):1474-80. doi: 10.1249/mss.0b013e3180d099ad.

Reference Type: BACKGROUND

PMID: 17805077 (View on PubMed)

Mendes FA, Goncalves RC, Nunes MP, Saraiva-Romanholo BM, Cukier A, Stelmach R, Jacob-Filho W, Martins MA, Carvalho CR. Effects of aerobic training on psychosocial morbidity and symptoms in patients with asthma: a randomized clinical trial. Chest. 2010 Aug;138(2):331-7. doi: 10.1378/chest.09-2389. Epub 2010 Apr 2.

Reference Type: DERIVED

PMID: 20363839 (View on PubMed)

Other Identifiers

Asthmatraining

Identifier Type: -

Identifier Source: org_study_id